Genetic Therapy Concept

subject area of

• A Comprehensive, Ethnically Diverse Library of Sickle Cell Disease-Specific Induced Pluripotent Stem Cells  Academic Article
• A Novel Approach to Tumor Suppression with Microencapsulated Recombinant Cells  Academic Article
• A Phase I Study of Adenovirus Mediated Gene Transfer of Interleukin 2 cDNA into Metastatic Breast Cancer or Melanoma. The Toronto Hospital, Toronto, Ontario, Canada  Academic Article
• A multiprong approach to cancer gene therapy by coencapsulated cells  Academic Article
• A phase I trial of adenovector-mediated delivery of interleukin-2 (AdIL-2) in high-risk localized prostate cancer  Academic Article
• AAV-mediated expression of 3TSR inhibits tumor and metastatic lesion development and extends survival in a murine model of epithelial ovarian carcinoma  Academic Article
• Aberrant Clonal Hematopoiesis following Lentiviral Vector Transduction of HSPCs in a Rhesus Macaque  Academic Article
• Adenovector engineered interleukin-2 expressing autologous plasma cell vaccination after high-dose chemotherapy for multiple myeloma - a phase 1 study  Academic Article
• Adenovector-mediated gene delivery of interleukin-2 in metastatic breast cancer and melanoma: results of a phase 1 clinical trial  Academic Article
• Adenoviral Vector Expressing Murine Angiostatin Inhibits a Model of Breast Cancer Metastatic Growth in the Lungs of Mice  Academic Article
• Adenoviral Vectors Expressing Lymphotactin and Interleukin 2 or Lymphotactin and Interleukin 12 Synergize to Facilitate Tumor Regression in Murine Breast Cancer Models  Academic Article
• Adenoviral vector-mediated interleukin-10 expression in vivo: intramuscular gene transfer inhibits cytokine responses in endotoxemia  Academic Article
• Adenoviral-Mediated Gene Transfer into Bone Marrow: An Effective Surgical Technique in Rat  Academic Article
• Adenovirus vectors for human gene therapy  Academic Article
• Adenovirus-Mediated Interleukin-10 Gene Transfer Inhibits Post-Transplant Fibrous Airway Obliteration in an Animal Model of Bronchiolitis Obliterans  Academic Article
• Adjunctive β2‐agonists reverse neuromuscular involvement in murine Pompe disease  Academic Article
• Advances in Thrombosis and Hemostasis  Academic Article
• Aerosol drug delivery: developments in device design and clinical use  Academic Article
• Antiangiogenic and Antifibrotic Gene Therapy in a Chronic Infusion Model of Peritoneal Dialysis in Rats  Academic Article
• Attenuation of the Glucocorticoid Response during Ad5IL-12 Adenovirus Vector Treatment Enhances Natural Killer Cell–Mediated Killing of MHC Class I–Negative LNCaP Prostate Tumors  Academic Article
• Autologous fibroblast implantation. Feasibility and potential problems in gene replacement therapy.  Academic Article
• BRCA1 is a novel target to improve endothelial dysfunction and retard atherosclerosis  Academic Article
• Biological Therapies for Atrial Fibrillation  Academic Article
• Biological properties of photocrosslinked alginate microcapsules  Academic Article
• Blood outgrowth endothelial cells overexpressing eNOS mitigate pulmonary hypertension in rats: a unique carrier cell enabling autologous cell-based gene therapy  Academic Article
• Brown Norway Chromosome 13 Confers Protection From High Salt to Consomic Dahl S Rat  Academic Article
• Budesonide Enhances Repeated Gene Transfer and Expression in the Lung with Adenoviral Vectors  Academic Article
• Canine models for human genetic neurodegenerative diseases  Academic Article
• Carrier Cell-based Delivery of an Oncolytic Virus Circumvents Antiviral Immunity  Academic Article
• Cell Phones and Landlines: The Impact of Gene Therapy on the Cost and Availability of Treatment for Hemophilia  Academic Article
• Cell-based cancer gene therapy: breaking tolerance or inducing autoimmunity?  Academic Article
• Cell-matrix Interactions of Factor IX (FIX)-engineered human mesenchymal stromal cells encapsulated in RGD-alginate vs. Fibrinogen-alginate microcapsules  Academic Article
• Circulating hematopoietic stem cells serve as novel targets for in utero gene therapy.  Academic Article
• Combination Epigenetic Therapy Has Efficacy in Patients with Refractory Advanced Non–Small Cell Lung Cancer  Academic Article
• Combination Therapy with Interleukin-2 and Wild-Type p53 Expressed by Adenoviral Vectors Potentiates Tumor Regression in a Murine Model of Breast Cancer  Academic Article
• Combined CXC chemokine and interleukin-12 gene transfer enhances antitumor immunity  Academic Article
• Combined Immunotherapy and Antiangiogenic Therapy of Cancer with Microencapsulated Cells  Academic Article
• Comparative evaluation of IGF-I gene transfer and IGF-I protein administration for enhancing skeletal muscle regeneration after injury  Academic Article
• Construction of First-Generation Adenoviral Vectors  Academic Article
• Construction of a Double Recombinant Adenovirus Vector Expressing a Heterodimeric Cytokine:In VitroandIn VivoProduction of Biologically Active Interleukin-12  Academic Article
• Core data set on safety, efficacy, and durability of hemophilia gene therapy for a global registry: Communication from the SSC of the ISTH  Academic Article
• Core outcome set for gene therapy in haemophilia: Results of the coreHEM multistakeholder project  Academic Article
• Correction of chromosomal mutation and random integration in embryonic stem cells with helper-dependent adenoviral vectors  Academic Article
• Correction of the Growth Defect in Dwarf Mice with Nonautologous Microencapsulated Myoblasts—An Alternate Approach to Somatic Gene Therapy  Academic Article
• Critical Interactions between Immunogenic Cancer Cell Death, Oncolytic Viruses, and the Immune System Define the Rational Design of Combination Immunotherapies  Academic Article
• Cytokine Therapeutics for Asthma: An Appraisal of Current Evidence and Future Prospects  Academic Article
• DEVELOPMENT OF PROSTATE-SPECIFIC ANTIGEN PROMOTER-BASED GENE THERAPY FOR ANDROGEN-INDEPENDENT HUMAN PROSTATE CANCER  Academic Article
• DNAzymes: From Creation In Vitro to Application In Vivo  Academic Article
• Delivery of Recombinant Gene Products with Microencapsulated Cells In Vivo  Academic Article
• Delivery of a Secretable Adenosine Deaminase Through Microcapsules–A Novel Approach to Somatic Gene Therapy  Academic Article
• Delivery of human factor IX in mice by encapsulated recombinant myoblasts: a novel approach towards allogeneic gene therapy of hemophilia B  Academic Article
• Delivery of recombinant gene product to canine brain with the use of microencapsulation  Academic Article
• Delivery of recombinant product from subcutaneous implants of encapsulated recombinant cells in canines  Academic Article
• Development of a FLP/frt System for Generating Helper-Dependent Adenoviral Vectors  Academic Article
• Development of a bovine adenovirus type 3-based expression vector  Academic Article
• Development of a size-restricted pIX-deleted helper virus for amplification of helper-dependent adenovirus vectors  Academic Article
• Direct Intratumoral Injection of an Adenovirus Expressing Interleukin-12 Induces Regression and Long-Lasting Immunity That Is Associated with Highly Localized Expression of Interleukin-12  Academic Article
• Efficacy of gene-therapy based on adenovirus encoding granulocyte-macrophage colony-stimulating factor in drug-sensitive and drug-resistant experimental pulmonary tuberculosis  Academic Article
• Enabling topical immunization via microporation: a novel method for pain-free and needle-free delivery of adenovirus-based vaccines  Academic Article
• Encapsulated engineered myoblasts can cure Hurler syndrome: preclinical experiments in the mouse model  Academic Article
• Encapsulation for Somatic Gene Therapy  Conference Paper
• Encapsulation of Recombinant Cells with a Novel Magnetized Alginate for Magnetic Resonance Imaging  Academic Article
• Enhancement of myoblast microencapsulation for gene therapy  Academic Article
• Epigenetic therapy inhibits metastases by disrupting premetastatic niches  Academic Article
• Establishing the appropriate primary endpoint in haemophilia gene therapy pivotal studies  Academic Article
• Evolution of haemophilia integrated care in the era of gene therapy: Treatment centre’s readiness in United States and EU  Academic Article
• Expressing human interleukin-15 from oncolytic vesicular stomatitis virus improves survival in a murine metastatic colon adenocarcinoma model through the enhancement of anti-tumor immunity  Academic Article
• Expression of Human Factor IX by Microencapsulated Recombinant Fibroblasts  Academic Article
• Expression of exogenous wt-p53 does not affect normal hematopoiesis: implications for bone marrow purging  Academic Article
• Factors influencing therapeutic efficacy and the host immune response to helper‐dependent adenoviral gene therapy in hemophilia A mice  Academic Article
• Foreign Gene Expression by Human Adenovirus Type 5-Based Vectors Studied Using Firefly Luciferase and Bacterial β-Galactosidase Genes as Reporters  Academic Article
• Gene Therapy for Hemophilia  Academic Article
• Gene Therapy for Hemophilia: Addressing the Coming Challenges of Affordability and Accessibility  Academic Article
• Gene Therapy for Pulmonary Diseases  Academic Article
• Gene Therapy, A Targeted Treatment for Diabetic Nephropathy  Academic Article
• Gene Therapy: Socioeconomic and Ethical Issues A Roundtable Discussion  Academic Article
• Gene Transfer of Matrix Metalloproteinase-9 Induces Tumor Regression of Breast Cancer In vivo  Academic Article
• Gene therapy for murine mucopolysaccharidosis type VII  Conference Paper
• Gene therapy to cure haemophilia: Is robust scientific inquiry the missing factor?  Academic Article
• Genomic DNA transfer with a high-capacity adenovirus vector results in improved in vivo gene expression and decreased toxicity  Academic Article
• Getting oncolytic virus therapies off the ground  Academic Article
• Growth Retardation—An Unexpected Outcome from Growth Hormone Gene Therapy in Normal Mice with Microencapsulated Myoblasts  Academic Article
• Harnessing Oncolytic Virus-mediated Antitumor Immunity in an Infected Cell Vaccine  Academic Article
• Have advanced research technologies made real impact on respiratory medicine?  Academic Article
• Helper-dependent adenoviral vectors mediate therapeutic factor VIII expression for several months with minimal accompanying toxicity in a canine model of severe hemophilia A  Academic Article
• Hepatocyte Targeting with Gd-EOB-DTPA  Academic Article
• Herpes simplex virus type-1 infection upregulates cellular promoters and telomerase activity in both tumor and nontumor human cells  Academic Article
• Heterogeneity of the immune response to adenovirus-mediated factor VIII gene therapy in different inbred hemophilic mouse strains  Academic Article
• Highly Priced Gene Therapies: A Wake-Up Call for Early Price Regulation  Academic Article
• Human Adenovirus Vectors for Gene Transfer into Mammalian Cells  Academic Article
• Human Gene Marker/Therapy Clincal Protocols (Complete Updated Listings)  Academic Article
• IL-10 is necessary for the expression of airway hyperresponsiveness but not pulmonary inflammation after allergic sensitization  Academic Article
• IL-4 gene therapy for collagen arthritis suppresses synovial IL-17 and osteoprotegerin ligand and prevents bone erosion  Academic Article
• Identification of primitive human hematopoietic cells capable of repopulating NOD/SCID mouse bone marrow: Implications for gene therapy  Academic Article
• Imaging Transgene Activity In vivo  Academic Article
• Immuno-Isolation in Cancer Gene Therapy  Academic Article
• Immuno-Isolation in Oncology - A Mini-Review  Academic Article
• Immuno-gene therapy approaches for cancer: from in vitro studies to clinical trials  Academic Article
• Immuno-gene therapy of established prostate tumors using chimeric receptor-redirected human lymphocytes.  Academic Article
• Immunotherapeutic effects of recombinant adenovirus encoding granulocyte–macrophage colony-stimulating factor in experimental pulmonary tuberculosis  Academic Article
• Immunotherapeutic effects of recombinant adenovirus encoding interleukin 12 in experimental pulmonary tuberculosis  Academic Article
• Immunotherapy of spontaneous type 1 diabetes in nonobese diabetic mice by systemic interleukin-4 treatment employing adenovirus vector-mediated gene transfer  Academic Article
• In Vivo Adenoviral-Mediated Gene Transfer of Interleukin-2 in Cutaneous Plasmacytoma  Academic Article
• In vitro correction of iduronate-2-sulfatase deficiency by adenovirus-mediated gene transfer  Academic Article
• In vivo interferon regulatory factor 3 tumor suppressor activity in B16 melanoma tumors.  Academic Article
• Induction of ErbB-2/neu-specific protective and therapeutic antitumor immunity using genetically modified dendritic cells: enhanced efficacy by cotransduction of gene encoding IL-12  Academic Article
• Inhibition of intimal hyperplasia after stenting by over-expression of p15: A member of the INK4 family of cyclin-dependent kinase inhibitors  Academic Article
• Interleukin 12 and B7-1 costimulatory molecule expressed by an adenovirus vector act synergistically to facilitate tumor regression  Academic Article
• Intramarrow Cytokine Gene Transfer by Adenoviral Vectors in Dogs  Academic Article
• Intrathymic implants of genetically modified fibroblasts  Academic Article
• Intratumoral administration of an adenovirus expressing a kinase dead form of ErbB-2 inhibits tumor growth  Academic Article
• Intratumoral coinjection of adenoviral vectors expressing IL-2 and IL-12 results in enhanced frequency of regression of injected and untreated distal tumors  Academic Article
• Intratumoral injection of an adenovirus expressing interleukin 2 induces regression and immunity in a murine breast cancer model.  Academic Article
• Lentivirus-mediated gene therapy for Fabry disease  Academic Article
• Leukemia targeting ligands isolated from phage display peptide libraries  Academic Article
• Luciferase Therapeutic Microcapsules for Gene Therapy  Academic Article
• Macrophage inflammatory protein-2 gene therapy attenuates adenovirus- and acetaminophen-mediated hepatic injury  Academic Article
• Mechanically enhanced microcapsules for cellular gene therapy  Academic Article
• MicroRNA-145 Targeted Therapy Reduces Atherosclerosis  Conference Paper
• Microcapsules as Bio-organs for Somatic Gene Therapya  Conference Paper
• Microencapsulation — An alternative approach to gene therapy  Conference Paper
• Modifier Gene Studies to Identify New Therapeutic Targets in Cystic Fibrosis  Academic Article
• Monkey business for hemophilia management  Academic Article
• Murine dendritic cells transduced with an adenoviral vector expressing a defined tumor antigen can overcome anti-adenovirus neutralizing immunity and induce effective tumor regression.  Academic Article
• Myostatin inhibition therapy for insulin-deficient type 1 diabetes  Academic Article
• Nervous system modification by transplants and gene transfer  Academic Article
• Non-Autologous Transplantation with Immuno-isolation in Large Animals-A Review  Conference Paper
• Non-viral transfer approaches for the gene therapy of mucopolysaccharidosis type II (Hunter syndrome)  Conference Paper
• Nonautologous gene therapy with implantable devices  Academic Article
• Nonviral Gene Therapy Approaches to Hemophilia  Academic Article
• Novel targets and approaches in advanced prostate cancer  Academic Article
• Novel therapy for asthma  Academic Article
• NovelLPLmutations associated with lipoprotein lipase deficiency: two case reports and a literature review  Academic Article
• ORFV: A Novel Oncolytic and Immune Stimulating Parapoxvirus Therapeutic  Academic Article
• Oncolytic Viruses: Therapeutics With an Identity Crisis  Academic Article
• One-step preparation of gold nanovectors using folate modified polyethylenimine and their use in target-specific gene transfection  Academic Article
• Optimizing Plasmid-Based Gene Transfer for Investigating Skeletal Muscle Structure and Function  Academic Article
• Overview of phase I studies of intravenous administration of PV701, an oncolytic virus.  Academic Article
• Past, present and future of haemophilia gene therapy: From vectors and transgenes to known and unknown outcomes  Academic Article
• Patient preferences and priorities for haemophilia gene therapy in the US: A discrete choice experiment  Academic Article
• Patient selection may affect gene therapy success. Dominant negative effects observed for ornithine transcarbamylase in mouse and human hepatocytes.  Academic Article
• Persistent Delivery of Factor IX in Mice: Gene Therapy for Hemophilia Using Implantable Microcapsules  Academic Article
• Phage-Mediated Gene Therapy  Academic Article
• Pharmacotherapy for erectile dysfunction  Academic Article
• Pluripotent human stem cell lines: what we can learn about cancer initiation  Academic Article
• Preparation of Helper-Dependent Adenoviral Vectors  Academic Article
• Programmable insect cell carriers for systemic delivery of integrated cancer biotherapy  Academic Article
• Protection from endotoxemia by adenoviral-mediated gene transfer of human bactericidal/permeability-increasing protein  Academic Article
• RNA-polymerase III-driven expression cassettes in human gene therapy.  Academic Article
• Recognition of Virus Infection and Innate Host Responses to Viral Gene Therapy Vectors  Academic Article
• Reduced tissue macrophage population in the lung by anticancer agent cyclophosphamide: restoration by local granulocyte macrophage–colony-stimulating factor gene transfer  Academic Article
• Repeated oral administration of chitosan/DNA nanoparticles delivers functional FVIII with the absence of antibodies in hemophilia A mice  Academic Article
• Retroviral Transduction of Hematopoietic Progenitors Derived From Human Embryonic Stem Cells  Academic Article
• Retroviral expression of MIR2 decreases both surface MHC class I and the alloimmune CTL response  Academic Article
• Review‐The Use of Immunosuppressive Agents to Prevent Neutralizing Antibodies Against a Transgene Product  Academic Article
• Selective depletion of factor XI or factor XII with antisense oligonucleotides attenuates catheter thrombosis in rabbits  Academic Article
• Sensitivity of 5-fluorouracil-resistant cancer cells to adenovirus suicide gene therapy  Academic Article
• Somatic Gene Therapy for a Neurodegenerative Disease Using Microencapsulated Recombinant Cells  Academic Article
• Strategies to Enhance Viral Penetration of Solid Tumors  Academic Article
• Suppression of Immunological Response Against a Transgene Product Delivered from Microencapsulated Cells  Academic Article
• Suppression of immunological response against a novel gene product delivered by implants of genetically modified fibroblasts.  Academic Article
• Sustained and therapeutic delivery of factor IX in nude haemophilia B mice by encapsulated C2C12 myoblasts: concurrent tumourigenesis  Academic Article
• Sustained and therapeutic levels of human factor IX in hemophilia B mice implanted with microcapsules: key role of encapsulated cells  Academic Article
• Synergistic Interaction Between Oncolytic Viruses Augments Tumor Killing  Academic Article
• Telomerase Mediates Vascular Endothelial Growth Factor-dependent Responsiveness in a Rat Model of Hind Limb Ischemia  Academic Article
• The 1st WFH Gene Therapy Round Table: Understanding the landscape and challenges of gene therapy for haemophilia around the world  Academic Article
• The Future of Pain Management in Emergency Medicine  Academic Article
• The efficacy of electroporated plasmid vaccines correlates with long-term antigen production in vivo  Academic Article
• The establishment of murine blood outgrowth endothelial cells and observations relevant to gene therapy  Academic Article
• The human SCGB2A2 (Mammaglobin-1) promoter/enhancer in a helper-dependent adenovirus vector directs high levels of transgene expression in mammary carcinoma cells but not in normal nonmammary cells  Academic Article
• The role of ICP0-Null HSV-1 and interferon signaling defects in the effective treatment of breast adenocarcinoma  Academic Article
• The use of adenoviral vectors for gene therapy and gene transfer in vivo  Academic Article
• Therapeutic Arteriogenesis by Ultrasound-Mediated VEGF ₁₆₅ Plasmid Gene Delivery to Chronically Ischemic Skeletal Muscle  Academic Article
• Therapeutic Effect of Angiostatin Gene Transfer in a Murine Model of Endometriosis  Academic Article
• Therapeutic levels of human Factor VIII in mice implanted with encapsulated cells: potential for gene therapy of haemophilia A  Academic Article
• Towards gene therapy in the nervous system.  Academic Article
• Toxicity Associated with Repeated Administration of First-Generation Adenovirus Vectors Does Not Occur with a Helper-Dependent Vector  Academic Article
• Transient Gene Transfer and Expression in the Lung  Academic Article
• Transient Gene Transfer of IL-12 Regulates Chemokine Expression and Disease Severity in Experimental Arthritis  Academic Article
• Transplanted hepatocytes infected with a complement receptor type 1 (CR1)-containing recombinant adenovirus are resistant to hyperacute rejection  Academic Article
• Treatment of a Lysosomal Storage Disease, Mucopolysaccharidosis VII, with Microencapsulated Recombinant Cells  Academic Article
• Treatment of hemophilia B in mice with nonautologous somatic gene therapeutics  Academic Article
• Tumor Protection Following Vaccination With Low Doses of Lentivirally Transduced DCs Expressing the Self-antigen erbB2  Academic Article
• Tumor-targeting domains for chimeric antigen receptor T cells  Academic Article
• Tumour immunotherapy using an adenoviral vector expressing a membrane-bound mutant of murine TNFα  Academic Article
• Tumour therapy in mice using adenovirus vectors expressing human TNFa.  Academic Article
• Use of helper-dependent adenoviral vectors of alternative serotypes permits repeat vector administration  Academic Article
• VEGF ameliorates pulmonary hypertension through inhibition of endothelial apoptosis in experimental lung fibrosis in rats  Academic Article
• Vascular Repair and Regeneration as a Therapeutic Target for Pulmonary Arterial Hypertension  Academic Article
• Vesicular Stomatitis Virus Oncolytic Treatment Interferes with Tumor-Associated Dendritic Cell Functions and Abrogates Tumor Antigen Presentation  Academic Article
• What is a cure and how do we get there?  Academic Article
• Wnt7a treatment ameliorates muscular dystrophy  Academic Article
• World Federation of Hemophilia Gene Therapy Registry  Academic Article
• Wt-p53 action in human leukaemia cell lines corresponding to different stages of differentiation  Academic Article
• [Cure of hemophilia is approaching. Gene therapy is the hope].  Academic Article
• [Gene therapy – from idea to reality].  Academic Article