Journal article
Immunotherapeutic effects of recombinant adenovirus encoding interleukin 12 in experimental pulmonary tuberculosis
Abstract
High dose of Mycobacterium tuberculosis (Mtb) strain H37Rv administered by intratracheal injection in BALB/c mice induce progressive tuberculosis (TB). In this model, during the first month there is a temporal control of bacillary growth, in coexistence with macrophage activation, granuloma formation and Th-1 response. Then, bacterial proliferation recommences, accompanied by progressive pneumonia and decreasing expression of protective …
Authors
Mata‐Espinosa DA; Francisco‐Cruz A; Marquina‐Castillo B; Barrios‐Payan J; Ramos‐Espinosa O; Bini EI; Xing Z; Hernández-Pando R
Journal
Scandinavian Journal of Immunology, Vol. 89, No. 3,
Publisher
Wiley
Publication Date
March 2019
DOI
10.1111/sji.12743
ISSN
0300-9475