Journal article
AAV-mediated expression of 3TSR inhibits tumor and metastatic lesion development and extends survival in a murine model of epithelial ovarian carcinoma
Abstract
An integral step in the development of solid tumors is the recruitment of blood vessels to fuel tumor growth. Antiangiogenic therapies can inhibit this process and control solid tumor growth. Thrombospondin-1 is an antiangiogenic protein possessing three type I repeats (3TSR) near the center of the protein and a CD47-binding peptide (CD47) in its C-terminus. Previously, we showed that treatment with recombinant 3TSR induces tumor regression, …
Authors
Yu DL; Stegelmeier AA; Chow N; Rghei AD; Matuszewska K; Lawler J; Bridle BW; Petrik JJ; Wootton SK
Journal
Cancer Gene Therapy, Vol. 27, No. 5, pp. 356–367
Publisher
Springer Nature
Publication Date
May 2020
DOI
10.1038/s41417-019-0108-8
ISSN
0929-1903