Journal article
Transient gene transfer of IL-12 regulates chemokine expression and disease severity in experimental arthritis.
Abstract
Murine collagen-induced arthritis (CIA) is characterized by pannus formation, cell infiltration, and cartilage erosion, and shares histologic and immunologic features with rheumatoid arthritis. Numerous cytokines are reportedly associated with RA and/or CIA; however, their mechanistic role is not clear. To determine the role of IL-12 in CIA, DBA/1 LacJ mice were administered 3 x 10(8) plaque-forming units of mIL-12 i.p. in a nonreplicating …
Authors
Parks E; Strieter RM; Lukacs NW; Gauldie J; Hitt M; Graham FL; Kunkel SL
Journal
The Journal of Immunology, Vol. 160, No. 9, pp. 4615–4619
Publisher
Oxford University Press (OUP)
Publication Date
May 1, 1998
DOI
10.4049/jimmunol.160.9.4615
ISSN
0022-1767