Journal article
A multiprong approach to cancer gene therapy by coencapsulated cells
Abstract
Immune-isolation of nonautologous cells with microencapsulation protects these cells from graft rejection, thus allowing the same recombinant therapeutic cell line to be implanted in different recipients. This approach was successful in treating HER2/neu-expressing tumors in mice by delivering an interleukin-2 fusion protein (sFvIL-2), or angiostatin. However, treatment with interleukin-2 led to profuse inflammation, while angiostatin delivery …
Authors
Cirone P; Shen F; Chang PL
Journal
Cancer Gene Therapy, Vol. 12, No. 4, pp. 369–380
Publisher
Springer Nature
Publication Date
April 1, 2005
DOI
10.1038/sj.cgt.7700786
ISSN
0929-1903
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AlginatesAngiostatinsAnimalsCell LineCell Line, TumorCell SurvivalCells, CulturedCytokinesEndothelium, VascularEnzyme-Linked Immunosorbent AssayFemaleGene Transfer TechniquesGenetic TherapyHumansImmunohistochemistryInflammationInterleukin-2Lymph NodesMelanoma, ExperimentalMiceMice, Inbred C57BLNecrosisNeoplasmsNeoplasms, ExperimentalNeovascularization, PathologicPolylysineRecombinant Fusion ProteinsSpleenTime FactorsTransgenesUmbilical Veinsvon Willebrand Factor