Journal article
In vivo interferon regulatory factor 3 tumor suppressor activity in B16 melanoma tumors.
Abstract
Delivery of transcription factors to cancer cells to reprogram gene expression may represent a novel strategy to augment the production of immune stimulatory cytokines and trigger a more potent antitumor response. In the present study, a bicistronic retroviral vector (AP2) was used to transduce B16-F0 melanoma cells with IFN regulatory factor (IRF)-3, which has been shown to activate type I IFN genes (IFN-beta and IFN-alpha) as well as other …
Authors
Duguay D; Mercier F; Stagg J; Martineau D; Bramson J; Servant M; Lin R; Galipeau J; Hiscott J
Journal
Cancer Research, Vol. 62, No. 18, pp. 5148–5152
Publication Date
September 15, 2002
ISSN
0008-5472