Journal article
Therapeutic Arteriogenesis by Ultrasound-Mediated VEGF165 Plasmid Gene Delivery to Chronically Ischemic Skeletal Muscle
Abstract
Current methods of gene delivery for therapeutic angiogenesis are invasive, requiring either intraarterial or intramuscular administration. A noninvasive method of gene delivery has been developed using ultrasound-mediated destruction of intravenously administered DNA-bearing carrier microbubbles during their microcirculatory transit. Here we show that chronic ischemia could be markedly improved by ultrasound-mediated destruction of …
Authors
Leong-Poi H; Kuliszewski MA; Lekas M; Sibbald M; Teichert-Kuliszewska K; Klibanov AL; Stewart DJ; Lindner JR
Journal
Circulation Research, Vol. 101, No. 3, pp. 295–303
Publisher
Wolters Kluwer
Publication Date
August 3, 2007
DOI
10.1161/circresaha.107.148676
ISSN
0009-7330
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AnimalsArteriolesCollateral CirculationDNA PackagingDNA, RecombinantEndothelium, VascularFluorocarbonsGene Transfer TechniquesGenes, ReporterGenetic TherapyGreen Fluorescent ProteinsHindlimbIliac ArteryIschemiaLigationLiposomesMicrobubblesMicrocirculationNeovascularization, PhysiologicPharmaceutical VehiclesRatsRats, Sprague-DawleySonicationTranscription, GeneticVascular Endothelial Growth Factor A