Encapsulation for Somatic Gene Therapy Conferences

abstract

• ABSTRACT: With the human genome project approaching its completion date of 2005, gene‐based technology will play an increasingly important role in health‐care delivery. Non‐autologous somatic gene therapy is a novel application in which non‐autologous cell lines engineered to secrete a recombinant protein are enclosed within immunoisolation devices and implanted into all patients requiring the same product for therapy. The development of this technology requiers a multi‐disciplinary effort towards optimization of the biomaterial used to manufacture the implantable devices and selection of the aporopriate cell lines for enclosure. The efficacy of this technology is illustrated in the treatment of dwarfism and lysosomal storage disease in murine models. The potential of a safe and cost‐effective gene‐based delivery method should have wide applications in treating both classical genetic disorders and non‐mendelian diseases.

authors

• Chang, Patricia Lai-yung

status

• published 

publication date

• June 1999

has subject area

• Animals (MeSH)
• Biocompatible Materials (MeSH)
• Disease Models, Animal (MeSH)
• Dwarfism (MeSH)
• General Science & Technology (Science Metrix)
• Genetic Therapy (MeSH)
• Humans (MeSH)
• Lysosomal Storage Diseases (MeSH)
• Mice (MeSH)
• Recombinant Proteins (MeSH)

published in

• Annals of the New York Academy of Sciences  Journal

presented at event

• Conference on Bioartificial Organs II - Technology, Medicine and Materials  Conference

keywords

• Animals
• Biocompatible Materials
• Disease Models, Animal
• Dwarfism
• Genetic Therapy
• Humans
• Lysosomal Storage Diseases
• Mice
• Recombinant Proteins

Digital Object Identifier (DOI)

• 10.1111/j.1749-6632.1999.tb08500.x

International Standard Book Number (ISBN) 10

• 1-57331-194-4

PubMed ID

• 10415564

start page

• 146

end page

• 158

volume

• 875

issue

• 1