In vivo adenoviral-mediated gene transfer of interleukin-2 in cutaneous plasmacytoma.
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Adenovirus vectors are attractive vehicles for clinical gene transfer as these replication-deficient vectors exhibit wide tissue tropism, infection of both replicating and nonreplicating cell types, and provide highly efficient expression of transgenes linked to appropriate promoters.1-3 Consequently, such vectors are now in widespread use in clinical gene therapy trials, particularly for cancer immunotherapy.
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