Journal article
A Comprehensive, Ethnically Diverse Library of Sickle Cell Disease-Specific Induced Pluripotent Stem Cells
Abstract
Sickle cell anemia affects millions of people worldwide and is an emerging global health burden. As part of a large NIH-funded NextGen Consortium, we generated a diverse, comprehensive, and fully characterized library of sickle-cell-disease-specific induced pluripotent stem cells (iPSCs) from patients of different ethnicities, β-globin gene (HBB) haplotypes, and fetal hemoglobin (HbF) levels. iPSCs stand to revolutionize the way we study human …
Authors
Park S; Gianotti-Sommer A; Molina-Estevez FJ; Vanuytsel K; Skvir N; Leung A; Rozelle SS; Shaikho EM; Weir I; Jiang Z
Journal
Stem Cell Reports, Vol. 8, No. 4, pp. 1076–1085
Publisher
Elsevier
Publication Date
April 2017
DOI
10.1016/j.stemcr.2016.12.017
ISSN
2213-6711
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AdolescentAdultAnemia, Sickle CellBase SequenceCRISPR-Cas SystemsCell LineCells, CulturedChildChild, PreschoolErythroid CellsFemaleFetal HemoglobinGenetic TherapyHaplotypesHemoglobin, SickleHumansInduced Pluripotent Stem CellsMaleMiddle AgedPoint MutationPolymorphism, GeneticTranscriptomeYoung Adultbeta-Globins