Correction of the Growth Defect in Dwarf Mice with Nonautologous Microencapsulated MyoblastsAn Alternate Approach to Somatic Gene Therapy

Most of the currently approved human gene therapy protocols depend on genetic modification of autologous cells. We propose an alternate and potentially more cost-effective approach by implanting genetically modified "universal" cell lines to deliver desired gene products to nonautologous recipients. The recombinant allogeneic cells are protected from rejection after implantation by enclosure within immuno-protective …