Selective depletion of factor XI or factor XII with antisense oligonucleotides attenuates catheter thrombosis in rabbits Academic Article uri icon

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abstract

  • Key PointsAntisense oligonucleotides reduce levels of target hepatic mRNA and protein and decrease clotting activity in rabbits. Selective depletion of factors XI and XII in rabbits attenuates catheter thrombosis, whereas factor VII depletion does not.

authors

  • Yau, Jonathan W
  • Liao, Peng
  • Fredenburgh, James C
  • Stafford, Alan R
  • Revenko, Alexey S
  • Monia, Brett P
  • Weitz, Jeffrey

publication date

  • March 27, 2014

published in