Selective depletion of factor XI or factor XII with antisense oligonucleotides attenuates catheter thrombosis in rabbits Journal Articles

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abstract

Key PointsAntisense oligonucleotides reduce levels of target hepatic mRNA and protein and decrease clotting activity in rabbits. Selective depletion of factors XI and XII in rabbits attenuates catheter thrombosis, whereas factor VII depletion does not.

authors

Yau, Jonathan W
Liao, Peng
Fredenburgh, James C
Stafford, Alan R
Revenko, Alexey S
Monia, Brett P
Weitz, Jeffrey

status

published

publication date

March 27, 2014

has subject area

1102 Cardiorespiratory Medicine and Haematology (FoR)
1103 Clinical Sciences (FoR)
1114 Paediatrics and Reproductive Medicine (FoR)
Animals (MeSH)
Catheter Obstruction (MeSH)
Catheters (MeSH)
Disease Models, Animal (MeSH)
Factor XI (MeSH)
Factor XII (MeSH)
Gene Expression Regulation (MeSH)
Genetic Therapy (MeSH)
Immunology (Science Metrix)
Male (MeSH)
Oligonucleotides, Antisense (MeSH)
RNA Interference (MeSH)
Rabbits (MeSH)
Substrate Specificity (MeSH)
Thrombosis (MeSH)

published in

Blood Journal