Journal article
Use of helper-dependent adenoviral vectors of alternative serotypes permits repeat vector administration
Abstract
We have developed a new helper adenovirus (Ad) based on serotype 2, Ad2LC8cCARP, for use in the Cre/loxP system (Parks et al. Proc Natl Acad Sci USA, 1996; 93: 13565–13570) to generate Ad vectors deleted of all protein coding sequences (helper-dependent Ad vectors (hdAd)). A comparison of Ad2LC8cCARP and our original helper virus (based on serotype 5, Ad5LC8cluc) showed that the two helper viruses amplified hdAd with a similar efficiency, and …
Authors
Parks RJ; Evelegh CM; Graham FL
Journal
Gene Therapy, Vol. 6, No. 9, pp. 1565–1573
Publisher
Springer Nature
Publication Date
September 1, 1999
DOI
10.1038/sj.gt.3300995
ISSN
0969-7128