Journal article
Exogenous liposomal IGF-I cDNA gene transfer leads to endogenous cellular and physiological responses in an acute wound
Abstract
The purpose of the present study was to examine whether exogenous liposomal cDNA gene transfer is recognized by the cell and causes endogenous cellular and physiological responses. When administered as a protein, IGF-I is known to cause adverse side effects due to lack of cellular responses. Therefore, we used IGF-I cDNA as a vector to study cellular and physiological effects after liposomal administration to wounded skin. Sprague-Dawley rats …
Authors
Jeschke MG; Schubert T; Klein D
Journal
AJP Regulatory Integrative and Comparative Physiology, Vol. 286, No. 5, pp. r958–r966
Publisher
American Physiological Society
Publication Date
5 2004
DOI
10.1152/ajpregu.00541.2003
ISSN
0363-6119
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AnimalsCarrier ProteinsCollagenDNA, ComplementaryDermisEpidermisFibroblast Growth Factor 7Fibroblast Growth FactorsGenetic TherapyInsulin-Like Growth Factor Binding Protein 1Insulin-Like Growth Factor Binding Protein 3Insulin-Like Growth Factor ILipocalin 1LiposomesMaleNeovascularization, PhysiologicRatsRats, Sprague-DawleyTransfectionWound Healing