Journal article
Tumour immunotherapy using an adenoviral vector expressing a membrane-bound mutant of murine TNFα
Abstract
The most limiting factor regarding the use of TNFα in tumour therapy is systemic toxicity. The expression of membrane-bound (nonsecreted) TNFα within a tumour may serve to reduce systemic toxicity while retaining antitumour activity. Two adenovirus (Ad) vectors were constructed: (1) Ad-mTNF-wt expressing wild-type murine TNFα; and (2) Ad-mTNF-MEM expressing a mutant nonsecreted (membrane-bound) form. Only the Ad-mTNF-wt vector induced high …
Authors
Marr R; Addison C; Snider D; Muller W; Gauldie J; Graham F
Journal
Gene Therapy, Vol. 4, No. 11, pp. 1181–1188
Publisher
Springer Nature
Publication Date
November 1, 1997
DOI
10.1038/sj.gt.3300528
ISSN
0969-7128