Journal article
Direct Intratumoral Injection of an Adenovirus Expressing Interleukin-12 Induces Regression and Long-Lasting Immunity That Is Associated with Highly Localized Expression of Interleukin-12
Abstract
Mice bearing breast tumors were treated with a single dose of an adenovirus expressing interleukin-12 (AdmIL-12.1) injected intratumorally, which produced regressions in greater than 75% of the treated tumors; approximately one-third of the animals remained tumor free. Complete regression was associated with immunity to secondary challenge with fresh tumor cells. Analysis of local cytokine expression demonstrated maximum expression of IL-12 …
Authors
Bramson JL; Hitt M; Addison CL; Muller WJ; Gauldie J; Graham FL
Journal
Human Gene Therapy, Vol. 7, No. 16, pp. 1995–2002
Publisher
Mary Ann Liebert
Publication Date
October 20, 1996
DOI
10.1089/hum.1996.7.16-1995
ISSN
1043-0342