Journal article
Intramarrow Cytokine Gene Transfer by Adenoviral Vectors in Dogs
Abstract
Daily systemic administration of hematopoietic growth factors can be associated with dose-limiting systemic side effects. To overcome this, we have investigated hematopoietic cytokine gene transfer to the marrow cavity of dogs by direct intramarrow injection of adenoviral vectors. In marrow culture, replication-deficient (E1-deleted) adenoviral vectors were able to transduce marrow stromal cells, demonstrating 30-fold greater expression than …
Authors
Foley R; Ellis R; Walker I; Wan Y; Carter R; Boyle M; Braciak T; Addison C; Graham F; Gauldie J
Journal
Human Gene Therapy, Vol. 8, No. 5, pp. 545–553
Publisher
Mary Ann Liebert
Publication Date
March 20, 1997
DOI
10.1089/hum.1997.8.5-545
ISSN
1043-0342