Conference
MicroRNA-145 Targeted Therapy Reduces Atherosclerosis
Abstract
BACKGROUND: MicroRNA are essential posttranscriptional modulators of gene expression implicated in various chronic diseases. Because microRNA-145 is highly expressed in vascular smooth muscle cells (VSMC) and regulates VSMC fate and plasticity, we hypothesized that it may be a novel regulator of atherosclerosis and plaque stability.
METHODS AND RESULTS: Apolipoprotein E knockout mice (ApoE(-/-)) mice were treated with either a microRNA-145 …
Authors
Lovren F; Pan Y; Quan A; Singh KK; Shukla PC; Gupta N; Steer BM; Ingram AJ; Gupta M; Al-Omran M
Volume
126
Pagination
pp. s81-s90
Publisher
Wolters Kluwer
Publication Date
September 11, 2012
DOI
10.1161/circulationaha.111.084186
Conference proceedings
Circulation
Issue
11_suppl_1
ISSN
0009-7322
Fields of Research (FoR)
Medical Subject Headings (MeSH)
ActinsAnimalsAortaAortic DiseasesApolipoproteins EAtherosclerosisCarotid ArteriesCells, CulturedDiet, AtherogenicGenes, ReporterGenetic TherapyGenetic VectorsHumansKruppel-Like Factor 4Kruppel-Like Transcription FactorsLentivirusLipidsMiceMice, Inbred C57BLMicroRNAsMyocytes, Smooth MusclePromoter Regions, GeneticRecombinant Fusion ProteinsTransduction, Genetic