Journal article
Enhancement of myoblast microencapsulation for gene therapy
Abstract
One method of nonviral-based gene therapy is to implant microencapsulated nonautologous cells genetically engineered to secrete the desired gene products. Encapsulating the cells within a biocompatible permselective hydrogel, such as alginate-poly-L-lysine-alginate (APA), protects the foreign cells from the host immune system while allowing diffusion of nutrients and the therapeutic gene products. An important consideration is which kind of …
Authors
Li AA; Shen F; Zhang T; Cirone P; Potter M; Chang PL
Journal
Journal of Biomedical Materials Research Part B Applied Biomaterials, Vol. 77B, No. 2, pp. 296–306
Publisher
Wiley
Publication Date
May 2006
DOI
10.1002/jbm.b.30342
ISSN
1552-4973