Journal article
Therapeutic levels of human Factor VIII in mice implanted with encapsulated cells: potential for gene therapy of haemophilia A
Abstract
BACKGROUND: A gene therapy delivery system based on microcapsules enclosing recombinant cells engineered to secrete a therapeutic protein has been evaluated. The microcapsules are implanted intraperitoneally. In order to prevent cell immune rejection, cells are enclosed in non-antigenic biocompatible alginate microcapsules prior to their implantation into mice. It has been shown that encapsulated myoblasts can deliver therapeutic levels of …
Authors
García‐Martín C; Chuah MKL; Van Damme A; Robinson KE; Vanzieleghem B; Saint‐Remy J; Gallardo D; Ofosu FA; Vandendriessche T; Hortelano G
Journal
The Journal of Gene Medicine, Vol. 4, No. 2, pp. 215–223
Publisher
Wiley
Publication Date
March 2002
DOI
10.1002/jgm.248
ISSN
1099-498X