Journal article
Combined Immunotherapy and Antiangiogenic Therapy of Cancer with Microencapsulated Cells
Abstract
An alternative form of gene therapy involves immunoisolation of a nonautologous cell line engineered to secrete a therapeutic product. Encapsulation of these cells in a biocompatible polymer serves to protect these allogeneic cells from host-versus-graft rejection while recombinant products and nutrients are able to pass by diffusion. This strategy was applied to the treatment of cancer with some success by delivering either interleukin 2 or …
Authors
Cirone P; Bourgeois JM; Shen F; Chang PL
Journal
Human Gene Therapy, Vol. 15, No. 10, pp. 945–959
Publisher
Mary Ann Liebert
Publication Date
October 2004
DOI
10.1089/hum.2004.15.945
ISSN
1043-0342
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
Angiogenesis InhibitorsAngiostatinsAnimalsApoptosisCell LineCell SurvivalCytokinesDrug CompoundingEndothelium, VascularEnzyme-Linked Immunosorbent AssayGenetic TherapyImmunohistochemistryImmunotherapyInterleukin-2Lymphocyte ActivationMelanoma, ExperimentalMiceMice, Inbred C57BLNecrosisNeoplasmsRecombinant ProteinsSpleenT-LymphocytesT-Lymphocytes, CytotoxicTime FactorsTransgenesvon Willebrand Factor