selected scholarly activity
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conferences
- IDENTIFICATION AND CHARACTERIZATION OF A NOVEL PHENYL-BIS (ALKYLIDENECARBOXYLIC ACID) THAT REDUCES HEPATOCELLULAR CARCINOMA (HCC) AND SYNERGIZES WITH SORAFENIB. Hepatology. S643-S644. 2022
- Canagliflozin Mediates Effective Blockade of the mTORC1 - HIF-1a Pathway, Inhibits Growth and Enhances Non-Small Cell Lung Cancer (NSCLC) Response to Radiotherapy (RT). International Journal of Radiation Oncology Biology Physics. S56-S56. 2020
- The Role of AMPK in Neuromuscular Junction Biology. The FASEB Journal. 1-1. 2020
- CANAGLIFLOZIN, A NEW ANTI-DIABETIC AGENT TARGETING CELLULAR METABOLISM, SUPPRESSES SURVIVAL AND ENHANCES THE RESPONSE OF NON-SMALL CELL LUNG CANCER (NSCLC) TO RADIOTHERAPY. Radiotherapy and Oncology. S20-S20. 2019
- Infrared Thermography as a Measure of Brown Adipose Tissue and its relationship to body composition, fasting glucose and lipids in 8-10 year old males. Irish Journal of Medical Science. S207-S207. 2019
- P1.14-33 Canagliflozin Inhibits Lung Cancer Survival and Enhances Its Response to Radiotherapy; Effective Blockade of mTOR Pathway, HIF1a, and Mitosis. Journal of Thoracic Oncology. S566-S567. 2019
- THE NEW DIABETES DRUG CANAGLIFLOZIN ENHANCES THE RESPONSE OF PROSTATE CANCER TO RADIOTHERAPY. Radiotherapy and Oncology. S71-S72. 2019
- TARGETING AMPK beta 1 AS A NOVEL STRATEGY TO AMELIORATE COLITIS. Gastroenterology. S652-S652. 2019
- AMPK-ACC signaling modulates platelet phospholipids content and potentiate platelet function and thrombus formation. European Heart Journal. 1263-1263. 2018
- Canagliflozin Directly Reduces Macrophage Inflammation via AMPK in a Mouse Model of Atherosclerosis. Atherosclerosis Plus. 115-115. 2018
- Targeting Liver ATP-Citrate Lyase with Bempedoic Acid: A Complementary LDL-C Lowering Strategy for Treating Hypercholesterolemia. Atherosclerosis Plus. 17-17. 2018
- 69P The diabetes drug canagliflozin sensitizes non-small cell lung cancer (NSCLC) to radiotherapy and chemotherapy. Journal of Thoracic Oncology. S37-S37. 2018
- Restoration of hepatic TDAG51 expression improves insulin signaling and reduces weight gain in mouse models of non‐alcoholic fatty liver disease. The FASEB Journal. 2018
- Phosphorylation of Acetylcoa Carboxylase by Ampk In Platelets Controls Thromboxane Generation, Dense Granules Secretion and Thrombus Formation. Circulation. 2017
- A default in acetyl-CoA carboxylase phosphorylation increases thrombus growth in vitro and in vivo, and in a collagen-dependent manner. European Heart Journal. 1137-1137. 2017
- The Effect of Skeletal Muscle AMPK on the Regulation and Localization of the Dystrophin‐Associated Protein Complex. The FASEB Journal. 2017
- Two Weeks of Reduced Steps Disrupts Integrated Rates of Muscle Protein Synthesis and Glycemic Control in Healthy Older Adults. The FASEB Journal. 2017
- COMBINED SALICYLATE (SAL) - METFORMIN (MET) TREATMENT INDUCES INCREASED TUMOUR SUPPRESSION AND RADIOSENSITIZATION IN PRECLINICAL MODELS OF PROSTATE CANCER (PRCA). Radiotherapy and Oncology. S35-S35. 2016
- Expression of the Dystrophin‐Associated Protein Complex in the Absence of Skeletal Muscle AMPK. The FASEB Journal. 2016
- Metabolic stress to sensitize non-small cell lung cancer (NSCLC) to radiotherapy: Studies from bench to bedside. Journal of Thoracic Oncology. S91-S91. 2016
- Targeting tumor metabolism to improve radio-sensitivity in non-small cell lung cancer (NSCLC). Journal of Thoracic Oncology. S50-S50. 2016
- AMP-Activated Protein Kinase As an Anti-Inflammatory Target for Methotrexate. Arthritis & Rheumatology. 2015
- ASSESSING THE IMPACT OF MEDICATION ADHERENCE ON LONG-TERM OUTCOMES IN PATIENTS WITH DIABETES. Journal of the American College of Cardiology. A1409-A1409. 2015
- 205 Metformin to modulate AMP-kinase and enhance chemotherapy and radiotherapy in non-small cell lung cancer. European Journal of Cancer. 67-67. 2014
- The Flavonoids Naringenin and Nobiletin Stimulate the AMPKinase Pathway in Primary Mouse Hepatocytes. Arteriosclerosis, Thrombosis and Vascular Biology. 2014
- Leukemia inhibitory factor stimulates muscle glucose uptake by a PI3-kinase dependent pathway that is maintained in white muscle in obesity. The FASEB Journal. 2014
- AMP-activated Protein Kinase is Critical for Regulating Cholesterol Homeostasis in Macrophages. Circulation. 2013
- The effects of BDNF supplementation on polymerase gamma (POLG) 1 mutator mice. Mitochondrion. 933-934. 2013
- Elevated Mitochondrial Oxidative Stress Blunts Skeletal Muscle Adaptations to Endurance Exercise. Medicine & Science in Sports & Exercise. 383-383. 2012
- Lack of Inteferon-gamma Results in Reduced Body Weight and Better Glucose Tolerance. Diabetes. A496-A496. 2011
- Elevated Mitochondrial Oxidative Stress Blunts Skeletal Muscle Adaptations to Endurance Exercise. Medicine & Science in Sports & Exercise. 383-383. 2011
- High Density Lipoprotein Modulates Glucose Metabolism by Multiple Mechanisms. Circulation. S468-S469. 2009
- Novel activators of AMP-Kinase as potential therapies for type 2 diabetes. Diabetes. A714-A714. 2007
- Interferon-gamma deficient mice become obese and have impaired glucose homeostasis when exposed to moderate levels of dietary fat. Diabetes. A292-A292. 2006
- Chronic leptin administration reduces fatty acid transport and the expression of FAT/CD36 and FABPpm in red and white skeletal muscle. The FASEB Journal. A749-A749. 2001
- Targeting AMPKβ1 as a novel strategy to ameliorate colitis.. Gastroenterology 2019. S-652-S-652.
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journal articles
- AMPK regulates the maintenance and remodelling of the neuromuscular junction.. Molecular Metabolism. 91:102066. 2024
- Growth differentiation factor 15 (GDF15) predicts relapse free and overall survival in unresected locally advanced non-small cell lung cancer treated with chemoradiotherapy.. Radiation Oncology. 19:155. 2024
- Suppression of neuronal AMPKβ2 isoform impairs recognition memory and synaptic plasticity.. Neurobiology of Disease. 201:106664. 2024
- Growth differentiation factor 15 alleviates diastolic dysfunction in mice with experimental diabetic cardiomyopathy. Cell Reports. 43:114573-114573. 2024
- Author Correction: Metformin-induced ablation of microRNA 21-5p releases Sestrin-1 and CAB39L antitumoral activities. Cell Discovery. 10:29. 2024
- Characteristics of Abdominal Visceral Adipose Tissue, Metabolic Health and the Gut Microbiome in Adults. Journal of Clinical Endocrinology and Metabolism (JCEM). 109:680-690. 2024
- Restoration of the ER stress response protein TDAG51 in hepatocytes mitigates NAFLD in mice. Journal of Biological Chemistry. 300:105655-105655. 2024
- Fatty Acids Increase GDF15 and Reduce Food Intake Through a GFRAL Signaling Axis. Diabetes. 73:51-56. 2024
- Prostate-Specific Membrane Antigen (PSMA) Expression Predicts Need for Early Treatment in Prostate Cancer Patients Managed with Active Surveillance. International Journal of Molecular Sciences. 24:16022-16022. 2023
- Canagliflozin mediates tumor suppression alone and in combination with radiotherapy in non‐small cell lung cancer (NSCLC) through inhibition of HIF‐1α. Molecular Oncology. 17:2235-2256. 2023
- Macrophage AMPK β1 activation by PF-06409577 reduces the inflammatory response, cholesterol synthesis, and atherosclerosis in mice. iScience. 26:108269-108269. 2023
- THE DIRECT AMPK-β1 SELECTIVE ACTIVATOR PF-06409577 TARGETS MACROPHAGES TO REDUCE ATHEROSCLEROSIS IN MICE. Canadian Journal of Diabetes. 47:S198-S198. 2023
- Circulating Growth Differentiation Factor 15 as a Biomarker in Patients with Unresected Locally Advanced Non-Small Cell Lung Cancer Treated with Chemo-Radiotherapy with or without Metformin. International Journal of Radiation Oncology Biology Physics. 117:e14-e15. 2023
- THE DIRECT AMPK-β1 SELECTIVE ACTIVATOR PF-06409577 TARGETS MACROPHAGES TO REDUCE ATHEROSCLEROSIS IN MICE. Canadian Journal of Cardiology. 39:S238-S238. 2023
- AMPK and the Endocrine Control of Metabolism. Endocrine Reviews. 44:910-933. 2023
- The SGLT2 inhibitor canagliflozin suppresses growth and enhances prostate cancer response to radiotherapy. Communications Biology. 6:919. 2023
- Combination of an ACLY inhibitor with a GLP-1R agonist exerts additive benefits on nonalcoholic steatohepatitis and hepatic fibrosis in mice. Cell Reports Medicine. 4:101193-101193. 2023
- GDF15 promotes weight loss by enhancing energy expenditure in muscle. Nature. 619:143-150. 2023
- Cannabidiolic acid (CBDA) regulates energy homeostasis and protects against non-alcoholic fatty liver disease (NAFLD) in mice. Journal of Hepatology. 78:S762-S762. 2023
- Effects of the pesticide deltamethrin on high fat diet-induced obesity and insulin resistance in male mice. Food and Chemical Toxicology. 176:113763-113763. 2023
- Author Correction: Chronic exposure to synthetic food colorant Allura Red AC promotes susceptibility to experimental colitis via intestinal serotonin in mice. Nature Communications. 14:3125. 2023
- Inhibition of NADPH Oxidase (NOX) 2 Mitigates Colitis in Mice with Impaired Macrophage AMPK Function. Biomedicines. 11:1443-1443. 2023
- A novel direct adenosine monophosphate kinase activator ameliorates disease progression in preclinical models of Autosomal Dominant Polycystic Kidney Disease. Kidney International. 103:917-929. 2023
- New insights into activation and function of the AMPK. Nature Reviews Molecular Cell Biology. 24:255-272. 2023
- 18F-DCFPyL (PSMA) PET as a radiotherapy response assessment tool in metastatic prostate cancer. Clinical and Translational Radiation Oncology. 39:100583-100583. 2023
- Preclinical evaluation of tolvaptan and salsalate combination therapy in a Pkd1-mouse model. Frontiers in Molecular Biosciences. 10:1058825. 2023
- Chronic exposure to synthetic food colorant Allura Red AC promotes susceptibility to experimental colitis via intestinal serotonin in mice. Nature Communications. 13:7617. 2022
- Blocking AMPK β1 myristoylation enhances AMPK activity and protects mice from high-fat diet-induced obesity and hepatic steatosis. Cell Reports. 41:111862-111862. 2022
- Environmental toxicants, brown adipose tissue, and potential links to obesity and metabolic disease. Current Opinion in Pharmacology. 67:102314-102314. 2022
- The phosphorylation of AMPKβ1 is critical for increasing autophagy and maintaining mitochondrial homeostasis in response to fatty acids. Proceedings of the National Academy of Sciences of the United States of America. 119:e2119824119. 2022
- High-fructose feeding suppresses cold-stimulated brown adipose tissue glucose uptake independently of changes in thermogenesis and the gut microbiome. Cell Reports Medicine. 3:100742-100742. 2022
- ACLY and CKD: A Mendelian Randomization Analysis. Kidney International Reports. 7:1673-1681. 2022
- Increased gut serotonin production in response to bisphenol A structural analogs may contribute to their obesogenic effects. American Journal of Physiology - Endocrinology and Metabolism. 323:E80-E091. 2022
- Metformin-induced reductions in tumor growth involves modulation of the gut microbiome. Molecular Metabolism. 61:101498-101498. 2022
- Inhibition of basal and glucagon-induced hepatic glucose production by 991 and other pharmacological AMPK activators. Biochemical Journal. 479:1317-1336. 2022
- Impaired Cold-Stimulated Supraclavicular Brown Adipose Tissue Activity in Young Boys With Obesity. Diabetes. 71:1193-1204. 2022
- Inhibition of ATP-citrate lyase improves NASH, liver fibrosis, and dyslipidemia. Cell Metabolism. 34:919-936.e8. 2022
- Natural (dihydro)phenanthrene plant compounds are direct activators of AMPK through its allosteric drug and metabolite–binding site. Journal of Biological Chemistry. 298:101852-101852. 2022
- Lipogenesis inhibitors: therapeutic opportunities and challenges. Nature Reviews Drug Discovery. 21:283-305. 2022
- Adipocyte Gq signaling is a regulator of glucose and lipid homeostasis in mice. Nature Communications. 13:1652. 2022
- Caffeine blocks SREBP2-induced hepatic PCSK9 expression to enhance LDLR-mediated cholesterol clearance. Nature Communications. 13:770. 2022
- Direct AMPK Activation Corrects NASH in Rodents Through Metabolic Effects and Direct Action on Inflammation and Fibrogenesis. Hepatology Communications. 6:101-119. 2022
- Shared pathobiology identifies AMPK as a therapeutic target for obesity and autosomal dominant polycystic kidney disease. Frontiers in Molecular Biosciences. 9:962933. 2022
- AMPK activation by SC4 inhibits noradrenaline-induced lipolysis and insulin-stimulated lipogenesis in white adipose tissue. Biochemical Journal. 478:3869-3889. 2021
- Disruption of autophagy by increased 5-HT alters gut microbiota and enhances susceptibility to experimental colitis and Crohn’s disease. Science Advances. 7:eabi6442. 2021
- Combined metformin-salicylate treatment provides improved anti-tumor activity and enhanced radiotherapy response in prostate cancer; drug synergy at clinically relevant doses. Translational Oncology. 14:101209-101209. 2021
- Salsalate reduces atherosclerosis through AMPKβ1 in mice. Molecular Metabolism. 53:101321-101321. 2021
- ATP-citrate lyase as a therapeutic target in chronic kidney disease: a Mendelian Randomization analysis 2021
- GDF15: emerging biology and therapeutic applications for obesity and cardiometabolic disease. Nature Reviews Endocrinology. 17:592-607. 2021
- Mitochondria-localized AMPK responds to local energetics and contributes to exercise and energetic stress-induced mitophagy. Proceedings of the National Academy of Sciences of the United States of America. 118:e2025932118. 2021
- Compound- and fiber type-selective requirement of AMPKγ3 for insulin-independent glucose uptake in skeletal muscle. Molecular Metabolism. 51:101228-101228. 2021
- Lower brown adipose tissue activity is associated with non-alcoholic fatty liver disease but not changes in the gut microbiota. Cell Reports Medicine. 2:100397-100397. 2021
- The pesticide chlorpyrifos promotes obesity by inhibiting diet-induced thermogenesis in brown adipose tissue. Nature Communications. 12:5163. 2021
- Sevoflurane-induced hyperglycemia is attenuated by salsalate in obese insulin-resistant mice. Canadian Journal of Anaesthesia. 68:972-979. 2021
- Salicylates Ameliorate Intestinal Inflammation by Activating Macrophage AMPK. Inflammatory Bowel Diseases. 27:914-926. 2021
- Exposure to the Widely Used Pyrethroid Pesticide Deltamethrin, Does Not Exacerbate High Fat Diet Induced Obesity or Insulin Resistance in C57BL/6J Mice. Journal of the Endocrine Society. 5:A45-A46. 2021
- The Pesticide Chlorpyrifos Promotes Obesity by Inhibiting Diet-Induced Thermogenesis. Journal of the Endocrine Society. 5:A59-A60. 2021
- Skeletal Muscle‐Specific Deletion of AMPKβ1β2 Modulates Age‐Induced Neuromuscular Junction Remodeling in Fast Glycolytic Muscles. The FASEB Journal. 35. 2021
- Metabolic remodeling of dystrophic skeletal muscle reveals biological roles for dystrophin and utrophin in adaptation and plasticity. Molecular Metabolism. 45:101157-101157. 2021
- AMPK mediates energetic stress‐induced liver GDF15. The FASEB Journal. 35:e21218. 2021
- Manufacturing T cells in hollow fiber membrane bioreactors changes their programming and enhances their potency. OncoImmunology. 10:1995168. 2021
- Correction: Effects of PKB/Akt inhibitors on insulin-stimulated lipogenesis and phosphorylation state of lipogenic enzymes in white adipose tissue. Biochemical Journal. 477:4599-4601. 2020
- Current and emerging roles of adipose tissue in health and disease. Biochemical Journal. 477:3645-3647. 2020
- The mega-importance of de novo lipogenesis in platelet production. Nature Metabolism. 2:999-1000. 2020
- SMOC1 is a glucose-responsive hepatokine and therapeutic target for glycemic control. Science Translational Medicine. 12:eaaz8048. 2020
- Long-chain fatty acyl-CoA esters regulate metabolism via allosteric control of AMPK β1 isoforms. Nature Metabolism. 2:873-881. 2020
- Targeting AMP-activated protein kinase (AMPK) for treatment of autosomal dominant polycystic kidney disease. Cellular Signalling. 73:109704-109704. 2020
- Impact of pesticide exposure on adipose tissue development and function. Biochemical Journal. 477:2639-2653. 2020
- The SGLT2 inhibitor canagliflozin suppresses lipid synthesis and interleukin-1 beta in ApoE deficient mice. Biochemical Journal. 477:2347-2361. 2020
- Effects of PKB/Akt inhibitors on insulin-stimulated lipogenesis and phosphorylation state of lipogenic enzymes in white adipose tissue. Biochemical Journal. 477:1373-1389. 2020
- The citrus flavonoid nobiletin confers protection from metabolic dysregulation in high-fat-fed mice independent of AMPK. Journal of Lipid Research. 61:387-402. 2020
- Energy-stress-mediated AMPK activation inhibits ferroptosis. Nature Cell Biology. 22:225-234. 2020
- Genetic deletion of mast cell serotonin synthesis prevents the development of obesity and insulin resistance. Nature Communications. 11:463. 2020
- Bacteria transmit metformin-associated lifespan extension. Nature Reviews Endocrinology. 16:9-10. 2020
- Two isoprenylated flavonoids from Dorstenia psilurus activate AMPK, stimulate glucose uptake, inhibit glucose production and lower glycemia. Biochemical Journal. 476:3687-3704. 2019
- MRI Reveals Human Brown Adipose Tissue Is Rapidly Activated in Response to Cold. Journal of the Endocrine Society. 3:2374-2384. 2019
- Metformin-induced increases in GDF15 are important for suppressing appetite and promoting weight loss. Nature Metabolism. 1:1202-1208. 2019
- Obesity and muscle‐macrophage crosstalk in humans and mice: A systematic review. Obesity Reviews. 20:1572-1596. 2019
- The caveolin-1 regulated protein follistatin protects against diabetic kidney disease. Kidney International. 96:1134-1149. 2019
- 167 The New Diabetes Drug Canagliflozin Enhances the Response of Prostate Cancer to Radiotherapy. Radiotherapy and Oncology. 139:S71-S72. 2019
- 40 Canagliflozin, a New Anti-Diabetic Agent Targeting Cellular Metabolism, Suppresses Survival and Enhances the Response of Non-Small Cell Lung Cancer (NSCLC) to Radiotherapy. Radiotherapy and Oncology. 139:S20-S20. 2019
- The gut microbiome regulates host glucose homeostasis via peripheral serotonin. Proceedings of the National Academy of Sciences of the United States of America. 116:19802-19804. 2019
- Salsalate, but not metformin or canagliflozin, slows kidney cyst growth in an adult-onset mouse model of polycystic kidney disease. EBioMedicine. 47:436-445. 2019
- Emerging Roles for Serotonin in Regulating Metabolism: New Implications for an Ancient Molecule. Endocrine Reviews. 40:1092-1107. 2019
- AMP-activated protein kinase: the current landscape for drug development. Nature Reviews Drug Discovery. 18:527-551. 2019
- Inhibition of AMPK-HMGCR signaling promotes the development of atherosclerosis and hepatic steatosis. Obesity Research and Clinical Practice. 13:286-286. 2019
- Su1895 – Targeting Ampkβ1 As a Novel Strategy to Ameliorate Colitis. Gastroenterology. 156:S-652. 2019
- Salicylate enhances the response of prostate cancer to radiotherapy. Prostate. 79:489-497. 2019
- A33 ROLE OF SEROTONIN-AUTOPHAGY AXIS IN INTESTINAL INFLAMMATION. Journal of the Canadian Association of Gastroenterology. 2:66-67. 2019
- Author Correction: Metformin inhibits gluconeogenesis via a redox-dependent mechanism in vivo. Nature Medicine. 25:526-528. 2019
- AMPK-ACC signalling is required for increasing appetite under conditions of metabolic stress. Obesity Research and Clinical Practice. 13:18-18. 2019
- Inhibition of Acetyl-CoA Carboxylase by Phosphorylation or the Inhibitor ND-654 Suppresses Lipogenesis and Hepatocellular Carcinoma. Cell Metabolism. 29:174-182.e5. 2019
- Inhibition of Adenosine Monophosphate–Activated Protein Kinase–3‐Hydroxy‐3‐Methylglutaryl Coenzyme A Reductase Signaling Leads to Hypercholesterolemia and Promotes Hepatic Steatosis and Insulin Resistance. Hepatology Communications. 3:84-98. 2019
- Emerging Role of AMPK in Brown and Beige Adipose Tissue (BAT): Implications for Obesity, Insulin Resistance, and Type 2 Diabetes. Current Diabetes Reports. 18:80. 2018
- Mechanisms of Metformin on Colon Cancer Inhibition: Roles of the Gut Microbiome, Butyrate and AMPK. Canadian Journal of Diabetes. 42:S2-S2. 2018
- AMPK-ACC signaling modulates platelet phospholipids and potentiates thrombus formation. Blood. 132:1180-1192. 2018
- Metformin inhibits gluconeogenesis via a redox-dependent mechanism in vivo. Nature Medicine. 24:1384-1394. 2018
- P6066AMPK-ACC signaling modulates platelet phospholipids content and potentiate platelet function and thrombus formation. European Heart Journal. 39:ehy566.p6066. 2018
- Failed Recovery of Glycemic Control and Myofibrillar Protein Synthesis With 2 wk of Physical Inactivity in Overweight, Prediabetic Older Adults. The journals of gerontology. Series A, Biological sciences and medical sciences. 73:1070-1077. 2018
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The
AMPK agonist 5‐aminoimidazole‐4‐carboxamide ribonucleotide (AICAR), but not metformin, prevents inflammation‐associated cachectic muscle wasting. EMBO Molecular Medicine. 10:e8307. 2018 - Association of Metformin with Breast Cancer Incidence and Mortality in Patients with Type II Diabetes: A GRADE-Assessed Systematic Review and Meta-analysis. Cancer Epidemiology, Biomarkers and Prevention. 27:627-635. 2018
- The role of AMP‐activated protein kinase in the expression of the dystrophin‐associated protein complex in skeletal muscle. The FASEB Journal. 32:2950-2965. 2018
- Recent advances in the detection of brown adipose tissue in adult humans: a review. Clinical Science. 132:1039-1054. 2018
- Activation of Liver AMPK with PF-06409577 Corrects NAFLD and Lowers Cholesterol in Rodent and Primate Preclinical Models. EBioMedicine. 31:122-132. 2018
- AMPK signaling to acetyl-CoA carboxylase is required for fasting- and cold-induced appetite but not thermogenesis. eLife. 7:e32656. 2018
- Cellular Energy Sensing and Metabolism—Implications for Treating Diabetes: The 2017 Outstanding Scientific Achievement Award Lecture. Diabetes. 67:169-179. 2018
- Impact of Direct to Consumer Store-and-Forward Teledermatology on Access to Care, Satisfaction, Utilization, and Costs in a Commercial Health Plan Population. Telemedicine Journal and e-Health. 24:166-169. 2018
- AMPK activation in the treatment of liver disease. Proceedings for Annual Meeting of The Japanese Pharmacological Society. WCP2018:SY83-3. 2018
- High Intensity Interval Training Increases Natural Killer Cell Number and Function in Obese Breast Cancer-challenged Mice and Obese Women. Journal of cancer prevention. 22:260-266. 2017
- Antihyperglycemic Medications: A Claims-Based Estimate of First-line Therapy Use Prior to Initialization of Second-line Medications. Diabetes Care. 40:1500-1505. 2017
- Association of Sex With Recurrence of Autism Spectrum Disorder Among Siblings. JAMA Pediatrics. 171:1107-1107. 2017
- Maternal obesity alters fatty acid oxidation, AMPK activity, and associated DNA methylation in mesenchymal stem cells from human infants. Molecular Metabolism. 6:1503-1516. 2017
- Targeting ATP-Citrate Lyase in Hyperlipidemia and Metabolic Disorders. Trends in Molecular Medicine. 23:1047-1063. 2017
- Ablating the protein TBC1D1 impairs contraction-induced sarcolemmal glucose transporter 4 redistribution but not insulin-mediated responses in rats. Journal of Biological Chemistry. 292:16653-16664. 2017
- Optimizing the methodology for measuring supraclavicular skin temperature using infrared thermography; implications for measuring brown adipose tissue activity in humans. Scientific Reports. 7:11934. 2017
- The autophagy initiator ULK1 sensitizes AMPK to allosteric drugs. Nature Communications. 8:571. 2017
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AMPK β1 reduces tumor progression and improves survival in p53 null mice. Molecular Oncology. 11:1143-1155. 2017 - A short term high-fat high-sucrose diet in mice impairs optic nerve recovery after injury and this is not reversed by exercise. Experimental Eye Research. 162:104-109. 2017
- Targeting metabolism and AMP-activated kinase with metformin to sensitize non-small cell lung cancer (NSCLC) to cytotoxic therapy: translational biology and rationale for current clinical trials. Oncotarget. 8:57733-57754. 2017
- Targeting metabolism and AMP-activated kinase with metformin to sensitize non-small cell lung cancer (NSCLC) to cytotoxic therapy: translational biology and rationale for current clinical trials.. Oncotarget. 8:57733-57754. 2017
- AMPK as a Therapeutic Target for Treating Metabolic Diseases. Trends in Endocrinology and Metabolism. 28:545-560. 2017
- P5375A default in acetyl-CoA carboxylase phosphorylation increases thrombus growth in vitro and in vivo, and in a collagen-dependent manner. European Heart Journal. 38:ehx493.p5375. 2017
- AMP-activated protein kinase, fatty acid metabolism, and insulin sensitivity. Current Opinion in Clinical Nutrition and Metabolic Care. 20:248-253. 2017
- Abstract 5850: Salicylate sensitizes prostate cancer (PrCa) to radiotherapy; activation of AMPK and suppression of lipogenesis. Cancer Research. 77:5850-5850. 2017
- Scriptaid enhances skeletal muscle insulin action and cardiac function in obese mice. Diabetes, Obesity and Metabolism. 19:936-943. 2017
- FGF21 does not require adipocyte AMP-activated protein kinase (AMPK) or the phosphorylation of acetyl-CoA carboxylase (ACC) to mediate improvements in whole-body glucose homeostasis. Molecular Metabolism. 6:471-481. 2017
- Rac1 and AMPK Account for the Majority of Muscle Glucose Uptake Stimulated by Ex Vivo Contraction but Not In Vivo Exercise. Diabetes. 66:1548-1559. 2017
- Sexual dimorphism in the glucose homeostasis phenotype of the Aromatase Knockout (ArKO) mice. Journal of Steroid Biochemistry and Molecular Biology. 170:39-48. 2017
- Are SIRT1 activators another indirect method to increase AMPK for beneficial effects on aging and the metabolic syndrome?. EBioMedicine. 19:16-17. 2017
- Muramyl Dipeptide-Based Postbiotics Mitigate Obesity-Induced Insulin Resistance via IRF4. Cell Metabolism. 25:1063-1074.e3. 2017
- Controlling skeletal muscle CPT-I malonyl-CoA sensitivity: the importance of AMPK-independent regulation of intermediate filaments during exercise. Biochemical Journal. 474:557-569. 2017
- Growth Differentiation Factor 15 as a Novel Biomarker for Metformin. Diabetes Care. 40:280-283. 2017
- Metformin-induced ablation of microRNA 21-5p releases Sestrin-1 and CAB39L antitumoral activities. Cell Discovery. 3:17022. 2017
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Exercise reverses age‐related vulnerability of the retina to injury by preventing complement‐mediated synapse elimination via a
BDNF ‐dependent pathway. Aging Cell. 15:1082-1091. 2016 - Liver-specific ATP-citrate lyase inhibition by bempedoic acid decreases LDL-C and attenuates atherosclerosis. Nature Communications. 7:13457. 2016
- Salsalate (Salicylate) Uncouples Mitochondria, Improves Glucose Homeostasis, and Reduces Liver Lipids Independent of AMPK-β1. Diabetes. 65:3352-3361. 2016
- An AMP-activated protein kinase–stabilizing peptide ameliorates adipose tissue wasting in cancer cachexia in mice. Nature Medicine. 22:1120-1130. 2016
- The diabetes medication Canagliflozin reduces cancer cell proliferation by inhibiting mitochondrial complex-I supported respiration. Molecular Metabolism. 5:1048-1056. 2016
- Treatment of nonalcoholic fatty liver disease: role of AMPK. American Journal of Physiology - Endocrinology and Metabolism. 311:E730-E740. 2016
- 90: Combined Salicylate (SAL) - Metformin (MET) Treatment Induces Increased Tumour Suppression and Radiosensitization in Preclinical Models of Prostate Cancer (PRCA). Radiotherapy and Oncology. 120:S35-S35. 2016
- The Na+/Glucose Cotransporter Inhibitor Canagliflozin Activates AMPK by Inhibiting Mitochondrial Function and Increasing Cellular AMP Levels. Diabetes. 65:2784-2794. 2016
- Characterization of Proliferating Lesion‐Resident Cells During All Stages of Atherosclerotic Growth. Journal of the American Heart Association. 5:e003945. 2016
- Assessing the Impact of Medication Adherence on Long-Term Cardiovascular Outcomes. Journal of the American College of Cardiology. 68:789-801. 2016
- Lack of Adipocyte AMPK Exacerbates Insulin Resistance and Hepatic Steatosis through Brown and Beige Adipose Tissue Function. Cell Metabolism. 24:118-129. 2016
- High-intensity exercise training increases the diversity and metabolic capacity of the mouse distal gut microbiota during diet-induced obesity. American Journal of Physiology - Endocrinology and Metabolism. 310:E982-E993. 2016
- Rationale and design of a home-based trial using wearable sensors to detect asymptomatic atrial fibrillation in a targeted population: The mHealth Screening To Prevent Strokes (mSToPS) trial. American Heart Journal. 175:77-85. 2016
- 84P Metabolic stress to sensitize non-small cell lung cancer (NSCLC) to radiotherapy: Studies from bench to bedside. Journal of Thoracic Oncology. 11:S91-S91. 2016
- Response to Letter to the Editor. Journal of Occupational and Environmental Medicine. 58:e115-e115. 2016
- High intensity interval training improves liver and adipose tissue insulin sensitivity. Molecular Metabolism. 4:903-915. 2015
- Reducing Metabolic Syndrome Risk Using a Personalized Wellness Program. Journal of Occupational and Environmental Medicine. 57:1269-1274. 2015
- MicroRNA-33–dependent regulation of macrophage metabolism directs immune cell polarization in atherosclerosis. Journal of Clinical Investigation. 125:4334-4348. 2015
- End-of-Life Planning Education and Advance Directives Completion Rates. Journal of Palliative Medicine. 18:825-826. 2015
- The AMPK activator R419 improves exercise capacity and skeletal muscle insulin sensitivity in obese mice. Molecular Metabolism. 4:643-651. 2015
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Exercise‐stimulated interleukin‐15 is controlled by
AMPK and regulates skin metabolism and aging. Aging Cell. 14:625-634. 2015 - AMPK deficiency in cardiac muscle results in dilated cardiomyopathy in the absence of changes in energy metabolism. Cardiovascular Research (CVR). 107:235-245. 2015
- Leukemia inhibitory factor increases glucose uptake in mouse skeletal muscle. American Journal of Physiology - Endocrinology and Metabolism. 309:E142-E153. 2015
- Salicylate activates AMPK and synergizes with metformin to reduce the survival of prostate and lung cancer cells ex vivo through inhibition of de novo lipogenesis. Biochemical Journal. 469:177-187. 2015
- Skeletal muscle ACC2 S212 phosphorylation is not required for the control of fatty acid oxidation during exercise. Physiological Reports. 3:e12444-e12444. 2015
- AMPK Activation of Muscle Autophagy Prevents Fasting-Induced Hypoglycemia and Myopathy during Aging. Cell Metabolism. 21:883-890. 2015
- Inhibition of AMP-Activated Protein Kinase at the Allosteric Drug-Binding Site Promotes Islet Insulin Release. Cell Chemical Biology. 22:705-711. 2015
- The p38-MK2-HuR pathway potentiates EGFRvIII–IL-1β-driven IL-6 secretion in glioblastoma cells. Oncogene. 34:2934-2942. 2015
- Metformin and salicylate synergistically activate liver AMPK, inhibit lipogenesis and improve insulin sensitivity. Biochemical Journal. 468:125-132. 2015
- Abstract 422: Metabolic Regulation by miR-33 in Macrophages Controls Immune Effector Responses. Arteriosclerosis, Thrombosis and Vascular Biology. 35. 2015
- Abstract 533: Salicylate Restores Macrophage Cholesterol Homeostasis via Activation of AMP-Activated Protein Kinase. Arteriosclerosis, Thrombosis and Vascular Biology. 35. 2015
- Duodenal energy sensing regulates hepatic glucose output. Nature Medicine. 21:428-429. 2015
- Motif affinity and mass spectrometry proteomic approach for the discovery of cellular AMPK targets: Identification of mitochondrial fission factor as a new AMPK substrate. Cellular Signalling. 27:978-988. 2015
- Salicylate improves macrophage cholesterol homeostasis via activation of Ampk. Journal of Lipid Research. 56:1025-1033. 2015
- Skeletal muscle AMPK is essential for the maintenance of FNDC5 expression. Physiological Reports. 3:e12343-e12343. 2015
- Cold-Stimulated Supraclavicular Skin Temperature as a Measure of Brown Adipose Tissue Activity and Its Relation to Physical Activity and Body Composition in 8-10 Year Old Boys. Canadian Journal of Diabetes. 39:S42-S42. 2015
- Type 2 Diabetes in Children and Adolescents: A Translational View. Canadian Journal of Diabetes. 39:S14-S15. 2015
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Defective
NOD 2 peptidoglycan sensing promotes diet‐induced inflammation, dysbiosis, and insulin resistance. EMBO Molecular Medicine. 7:259-274. 2015 - Inhibiting peripheral serotonin synthesis reduces obesity and metabolic dysfunction by promoting brown adipose tissue thermogenesis. Nature Medicine. 21:166-172. 2015
- Effects of Estrogens on Adipokines and Glucose Homeostasis in Female Aromatase Knockout Mice. PLoS ONE. 10:e0136143-e0136143. 2015
- The role of AMPK in controlling metabolism and mitochondrial biogenesis during exercise. Quarterly journal of experimental physiology and cognate medical sciences. 99:1581-1585. 2014
- Fluvastatin Causes NLRP3 Inflammasome-Mediated Adipose Insulin Resistance. Diabetes. 63:3742-3747. 2014
- Early oxidative shifts in mouse skeletal muscle morphology with high-fat diet consumption do not lead to functional improvements. Physiological Reports. 2:e12149-e12149. 2014
- AMPK-Dependent Inhibitory Phosphorylation of ACC Is Not Essential for Maintaining Myocardial Fatty Acid Oxidation. Circulation Research. 115:518-524. 2014
- AMPK phosphorylation of ACC2 is required for skeletal muscle fatty acid oxidation and insulin sensitivity in mice. Diabetologia. 57:1693-1702. 2014
- Compensatory regulation of HDAC5 in muscle maintains metabolic adaptive responses and metabolism in response to energetic stress. The FASEB Journal. 28:3384-3395. 2014
- Reduced skeletal muscle AMPK and mitochondrial markers do not promote age-induced insulin resistance. Journal of applied physiology. 117:171-179. 2014
- Suppressor of cytokine signalling (SOCS) proteins as guardians of inflammatory responses critical for regulating insulin sensitivity. Biochemical Journal. 461:177-188. 2014
- A standardized infrared imaging technique that specifically detects UCP1-mediated thermogenesis in vivo. Molecular Metabolism. 3:490-494. 2014
- Mechanism of Action of Compound-13: An α1-Selective Small Molecule Activator of AMPK. Cell Chemical Biology. 21:866-879. 2014
- PPARδ activation attenuates hepatic steatosis in Ldlr mice by enhanced fat oxidation, reduced lipogenesis, and improved insulin sensitivity. Journal of Lipid Research. 55:1254-1266. 2014
- Abstract 244: The Flavonoids Naringenin and Nobiletin Stimulate the AMPKinase Pathway in Primary Mouse Hepatocytes. Arteriosclerosis, Thrombosis and Vascular Biology. 34. 2014
- Endurance interval training in obese mice reduces muscle inflammation and macrophage content independently of weight loss. Physiological Reports. 2:e12012-e12012. 2014
- Muscle‐specific AMPK β1β2‐null mice display a myopathy due to loss of capillary density in nonpostural muscles. The FASEB Journal. 28:2098-2107. 2014
- Small Molecule Drug A-769662 and AMP Synergistically Activate Naive AMPK Independent of Upstream Kinase Signaling. Cell Chemical Biology. 21:619-627. 2014
- AMPK promotes macrophage fatty acid oxidative metabolism to mitigate inflammation: implications for diabetes and cardiovascular disease. Immunology and Cell Biology. 92:340-345. 2014
- Immunometabolism: the interface of immune and metabolic responses in disease. Immunology and Cell Biology. 92:303-303. 2014
- Leukemia inhibitory factor stimulates muscle glucose uptake by a PI3‐kinase dependent pathway that is maintained in white muscle in obesity (1162.4). The FASEB Journal. 28. 2014
- Enhanced activation of cellular AMPK by dual-small molecule treatment: AICAR and A769662. American Journal of Physiology - Endocrinology and Metabolism. 306:E688-E696. 2014
- Evidence for the role of AMPK in regulating PGC‐1 alpha expression and mitochondrial proteins in mouse epididymal adipose tissue. Obesity. 22:730-738. 2014
- AMP-activated protein kinase (AMPK) beyond metabolism. Cancer Biology and Therapy. 15:156-169. 2014
- Hepatic Glucose Intolerance Precedes Hepatic Steatosis in the Male Aromatase Knockout (ArKO) Mouse. PLoS ONE. 9:e87230-e87230. 2014
- Interleukin-15 Modulates Adipose Tissue by Altering Mitochondrial Mass and Activity. PLoS ONE. 9:e114799-e114799. 2014
- Editorial: “Presenting” an adaptive role for AMPK. Journal of Leukocyte Biology. 94:1099-1101. 2013
- Endurance Training Modulates Intramyocellular Lipid Compartmentalization and Morphology in Skeletal Muscle of Lean and Obese Women. Journal of Clinical Endocrinology and Metabolism (JCEM). 98:4852-4862. 2013
- Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin. Nature Medicine. 19:1649-1654. 2013
- Diacylglycerol Kinase Delta Promotes Lipogenesis. Biochemistry. 52:7766-7776. 2013
- PIKfyve: a new fish in the growing pool of AMPK substrates. Biochemical Journal. 455:e1-e3. 2013
- AMPK: mediating the metabolic effects of salicylate-based drugs?. Trends in Endocrinology and Metabolism. 24:481-487. 2013
- IL-6 is not essential for exercise-induced increases in glucose uptake. Journal of applied physiology. 114:1151-1157. 2013
- AMPK and the endocrine control of energy metabolism. Molecular and Cellular Endocrinology. 366:125-126. 2013
- AMPK regulation of fatty acid metabolism and mitochondrial biogenesis: Implications for obesity. Molecular and Cellular Endocrinology. 366:135-151. 2013
- Immunometabolism of AMPK in insulin resistance and atherosclerosis. Molecular and Cellular Endocrinology. 366:224-234. 2013
- Deletion of Skeletal Muscle SOCS3 Prevents Insulin Resistance in Obesity. Diabetes. 62:56-64. 2013
- Elevated Mitochondrial Oxidative Stress Impairs Metabolic Adaptations to Exercise in Skeletal Muscle. PLoS ONE. 8:e81879-e81879. 2013
- Enhanced Lipid Oxidation and Maintenance of Muscle Insulin Sensitivity Despite Glucose Intolerance in a Diet-Induced Obesity Mouse Model. PLoS ONE. 8:e71747-e71747. 2013
- Loss of TDAG51 Results in Mature-Onset Obesity, Hepatic Steatosis, and Insulin Resistance by Regulating Lipogenesis. Diabetes. 62:158-169. 2013
- Markers of Skeletal Muscle Mitochondrial Function and Lipid Accumulation Are Moderately Associated with the Homeostasis Model Assessment Index of Insulin Resistance in Obese Men. PLoS ONE. 8:e66322-e66322. 2013
- Chronic modulation of AMP-Kinase, Akt and mTOR pathways by ionizing radiation in human lung cancer xenografts. Radiation Oncology. 7:71. 2012
- Reduced Socs3 expression in adipose tissue protects female mice against obesity-induced insulin resistance. Diabetologia. 55:3083-3093. 2012
- The long and winding TRAIL to weight loss. Clinical Science. 123:545-546. 2012
- The Ancient Drug Salicylate Directly Activates AMP-Activated Protein Kinase. Science. 336:918-922. 2012
- Hematopoietic AMPK β1 reduces mouse adipose tissue macrophage inflammation and insulin resistance in obesity. Journal of Clinical Investigation. 121:4903-4915. 2011
- Deficiency in Interferon-γ Results in Reduced Body Weight and Better Glucose Tolerance in Mice. Endocrinology. 152:3690-3699. 2011
- AMP-activated protein kinase (AMPK) β1β2 muscle null mice reveal an essential role for AMPK in maintaining mitochondrial content and glucose uptake during exercise. Proceedings of the National Academy of Sciences of the United States of America. 108:16092-16097. 2011
- NOD1 Activators Link Innate Immunity to Insulin Resistance. Diabetes. 60:2206-2215. 2011
- Macrophage Deletion of SOCS1 Increases Sensitivity to LPS and Palmitic Acid and Results in Systemic Inflammation and Hepatic Insulin Resistance. Diabetes. 60:2023-2031. 2011
- Impact of SOCS3 overexpression on human skeletal muscle development in vitro. Cytokine. 55:104-109. 2011
- Contraction-induced skeletal muscle FAT/CD36 trafficking and FA uptake is AMPK independent. Journal of Lipid Research. 52:699-711. 2011
- Liver-specific suppressor of cytokine signaling-3 deletion in mice enhances hepatic insulin sensitivity and lipogenesis resulting in fatty liver and obesity1. Hepatology. 52:1632-1642. 2010
- Whole Body Deletion of AMP-activated Protein Kinase β2 Reduces Muscle AMPK Activity and Exercise Capacity. Journal of Biological Chemistry. 285:37198-37209. 2010
- Adipose tissue as an endocrine organ. Molecular and Cellular Endocrinology. 316:129-139. 2010
- SIRT1 Takes a Backseat to AMPK in the Regulation of Insulin Sensitivity by Resveratrol. Diabetes. 59:551-553. 2010
- Skeletal muscle glucose uptake during contraction is regulated by nitric oxide and ROS independently of AMPK. American Journal of Physiology - Endocrinology and Metabolism. 298:E577-E585. 2010
- Erratum to: Reduced AMP-activated protein kinase activity in mouse skeletal muscle does not exacerbate the development of insulin resistance with obesity. Diabetologia. 53:398-398. 2010
- AMPK β1 Deletion Reduces Appetite, Preventing Obesity and Hepatic Insulin Resistance. Journal of Biological Chemistry. 285:115-122. 2010
- Reduced AMP-activated protein kinase activity in mouse skeletal muscle does not exacerbate the development of insulin resistance with obesity. Diabetologia. 52:2395-2404. 2009
- Retractions and Errata. The FASEB Journal. 23:2790-2790. 2009
- AMPK in Health and Disease. Physiological Reviews. 89:1025-1078. 2009
- Oligomeric resistin impairs insulin and AICAR-stimulated glucose uptake in mouse skeletal muscle by inhibiting GLUT4 translocation. American Journal of Physiology - Endocrinology and Metabolism. 297:E57-E66. 2009
- Subcellular Localization of Cyclic AMP-Responsive Element Binding Protein-Regulated Transcription Coactivator 2 Provides a Link between Obesity and Breast Cancer in Postmenopausal Women. Cancer Research. 69:5392-5399. 2009
- Role of the AMP-activated protein kinase in regulating fatty acid metabolism during exerciseThis paper is one of a selection of papers published in this Special Issue, entitled 14th International Biochemistry of Exercise Conference – Muscles as Molecular and Metabolic Machines, and has undergone the Journal’s usual peer review process.. Applied Physiology, Nutrition and Metabolism. 34:315-322. 2009
- AMPK‐dependent hormonal regulation of whole‐body energy metabolism. Acta Physiologica. 196:115-127. 2009
- High-Density Lipoprotein Modulates Glucose Metabolism in Patients With Type 2 Diabetes Mellitus. Circulation. 119:2103-2111. 2009
- Ciliary Neurotrophic Factor Stimulates Muscle Glucose Uptake by a PI3-Kinase–Dependent Pathway That Is Impaired With Obesity. Diabetes. 58:829-839. 2009
- Low salt concentrations activate AMP-activated protein kinase in mouse macula densa cells. American Journal of Physiology - Renal Physiology. 296:F801-F809. 2009
- Corrigendum. American Journal of Physiology - Endocrinology and Metabolism. 296:E401-E401. 2009
- Cytokine Regulation of AMPK signalling. Frontiers in Bioscience - Landmark. Volume:1902-1902. 2009
- High-density lipoprotein modulates glucose metabolism in patients with type 2 diabetes. Heart Lung and Circulation. 18:S244-S244. 2009
- AMPK‐independent pathways regulate skeletal muscle fatty acid oxidation. Journal of Physiology. 586:5819-5831. 2008
- Thienopyridone Drugs Are Selective Activators of AMP-Activated Protein Kinase β1-Containing Complexes. Cell Chemical Biology. 15:1220-1230. 2008
- Regulation and function of triacylglycerol lipases in cellular metabolism. Biochemical Journal. 414:313-325. 2008
- Bradykinin stimulates endothelial cell fatty acid oxidation by CaMKK-dependent activation of AMPK. Atherosclerosis. 200:28-36. 2008
- Prolonged interleukin-6 administration enhances glucose tolerance and increases skeletal muscle PPARα and UCP2 expression in rats. Journal of Endocrinology. 198:367-374. 2008
- Pathways Involved In Lipid-Induced Insulin Resistance In Obesity. Clinical Lipidology and Metabolic Disorders. 2:659-667. 2007
- Adipocyte triglyceride lipase expression in human obesity. American Journal of Physiology - Endocrinology and Metabolism. 293:E958-E964. 2007
- Adiponectin: Starving for Attention. Cell Metabolism. 6:3-4. 2007
- The AMP-Activated Protein Kinase: Role in Regulation of Skeletal Muscle Metabolism and Insulin Sensitivity. Mini-Reviews in Medicinal Chemistry. 7:521-528. 2007
- Inflammation in Obesity is a Common Link Between Defects in Fatty Acid Metabolism and Insulin Resistance. Cell Cycle. 6:888-894. 2007
- Leptin stimulation of COXIV is impaired in obese skeletal muscle myotubes. Obesity Research and Clinical Practice. 1:53-60. 2007
- Tumor necrosis factor α-induced skeletal muscle insulin resistance involves suppression of AMP-kinase signaling. Cell Metabolism. 4:465-474. 2006
- Differential Regulation of Adiponectin Receptor Gene Expression by Adiponectin and Leptin in Myotubes Derived from Obese and Diabetic Individuals. Obesity. 14:1898-1904. 2006
- Adrenergic regulation of HSL serine phosphorylation and activity in human skeletal muscle during the onset of exercise. American Journal of Physiology. Regulatory Integrative and Comparative Physiology. 291:R1094-R1099. 2006
- Interleukin-6 Increases Insulin-Stimulated Glucose Disposal in Humans and Glucose Uptake and Fatty Acid Oxidation In Vitro via AMP-Activated Protein Kinase. Diabetes. 55:2688-2697. 2006
- The Suppressor of Cytokine Signaling 3 Inhibits Leptin Activation of AMP-Kinase in Cultured Skeletal Muscle of Obese Humans. Journal of Clinical Endocrinology and Metabolism (JCEM). 91:3592-3597. 2006
- Ciliary Neurotrophic Factor Suppresses Hypothalamic AMP-Kinase Signaling in Leptin-Resistant Obese Mice. Endocrinology. 147:3906-3914. 2006
- AMP-activated protein kinase — the fat controller of the energy railroadThis paper is one of a selection of papers published in this Special issue, entitled Second Messengers and Phosphoproteins—12th International Conference.. Canadian Journal of Physiology and Pharmacology. 84:655-665. 2006
- Fatty acids stimulate AMP‐activated protein kinase and enhance fatty acid oxidation in L6 myotubes. Journal of Physiology. 574:139-147. 2006
- Reduced glycogen availability is associated with increased AMPKα2 activity, nuclear AMPKα2 protein abundance, and GLUT4 mRNA expression in contracting human skeletal muscle. Applied Physiology, Nutrition and Metabolism. 31:302-312. 2006
- CNTF reverses obesity-induced insulin resistance by activating skeletal muscle AMPK. Nature Medicine. 12:541-548. 2006
- Regulation of HSL serine phosphorylation in skeletal muscle and adipose tissue. American Journal of Physiology - Endocrinology and Metabolism. 290:E500-E508. 2006
- PGC‐1α gene expression is down‐regulated by Akt‐mediated phosphorylation and nuclear exclusion of FoxO1 in insulin‐stimulated skeletal muscle. The FASEB Journal. 19:2072-2074. 2005
- Socs1 Deficiency Enhances Hepatic Insulin Signaling. Journal of Biological Chemistry. 280:31516-31521. 2005
- Impaired Activation of AMP-Kinase and Fatty Acid Oxidation by Globular Adiponectin in Cultured Human Skeletal Muscle of Obese Type 2 Diabetics. Journal of Clinical Endocrinology and Metabolism (JCEM). 90:3665-3672. 2005
- Acute IL-6 treatment increases fatty acid turnover in elderly humans in vivo and in tissue culture in vitro. American Journal of Physiology - Endocrinology and Metabolism. 288:E155-E162. 2005
- AMP-Activated Protein Kinase Is Not Down-Regulated in Human Skeletal Muscle of Obese Females. Journal of Clinical Endocrinology and Metabolism (JCEM). 89:4575-4580. 2004
- β‐adrenergic stimulation of skeletal muscle HSL can be overridden by AMPK signaling. The FASEB Journal. 18:1445-1446. 2004
- Reduced plasma FFA availability increases net triacylglycerol degradation, but not GPAT or HSL activity, in human skeletal muscle. American Journal of Physiology - Endocrinology and Metabolism. 287:E120-E127. 2004
- Triacylglycerol accumulation in human obesity and type 2 diabetes is associated with increased rates of skeletal muscle fatty acid transport and increased sarcolemmal FAT/CD36. The FASEB Journal. 18:1144-1146. 2004
- Endurance training partially reverses dietary-induced leptin resistance in rodent skeletal muscle. American Journal of Physiology - Endocrinology and Metabolism. 286:E57-E63. 2004
- Hormone-sensitive lipase activity and triacylglycerol hydrolysis are decreased in rat soleus muscle by cyclopiazonic acid. American Journal of Physiology - Endocrinology and Metabolism. 285:E412-E419. 2003
- Acute and Chronic Effects of Leptin on Skeletal Muscle Fatty Acid Metabolism. Applied Physiology, Nutrition and Metabolism. 28:501-501. 2003
- AMPK expression and phosphorylation are increased in rodent muscle after chronic leptin treatment. American Journal of Physiology - Endocrinology and Metabolism. 284:E648-E654. 2003
- Leptin increases FA oxidation in lean but not obese human skeletal muscle: evidence of peripheral leptin resistance. American Journal of Physiology - Endocrinology and Metabolism. 283:E187-E192. 2002
- Chronic Leptin Administration Decreases Fatty Acid Uptake and Fatty Acid Transporters in Rat Skeletal Muscle. Journal of Biological Chemistry. 277:8854-8860. 2002
- Fatty acid oxidation and triacylglycerol hydrolysis are enhanced after chronic leptin treatment in rats. American Journal of Physiology - Endocrinology and Metabolism. 282:E593-E600. 2002
- Insulin increases FA uptake and esterification but reduces lipid utilization in isolated contracting muscle. American Journal of Physiology - Endocrinology and Metabolism. 281:E600-E607. 2001
- Development of leptin resistance in rat soleus muscle in response to high-fat diets. American Journal of Physiology - Endocrinology and Metabolism. 279:E1374-E1382. 2000
- Metformin-induced increases in GDF15 are important for suppressing appetite and promoting weight loss. Yearbook of Paediatric Endocrinology.
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preprints
- Growth differentiation factor 15 (GDF15) predicts relapse free and overall survival in unresected Locally Advanced Non-Small Cell Lung Cancer treated with chemo- radiotherapy. 2024
- High-fructose feeding suppresses cold-stimulated brown adipose tissue glucose uptake in young men independently of changes in thermogenesis and the gut microbiome 2022
- Compound- and fiber type-selective requirement of AMPKγ3 for insulin-independent glucose uptake in skeletal muscle 2021
- Salsalate, But Not Metformin or Canagliflozin, Slows Kidney Cyst Growth in an Adult-Onset Mouse Model of Polycystic Kidney Disease 2019
- Intrinsic bioenergetic adaptations compensate for reduced mitochondrial content in HER2-driven mammary tumors