Journal article
Abstract 533: Salicylate Restores Macrophage Cholesterol Homeostasis via Activation of AMP-Activated Protein Kinase
Abstract
Objectives: Atherosclerosis stems from imbalances in lipid metabolism and leads to maladaptive inflammatory responses. AMP-activated protein kinase (AMPK) is a highly conserved serine/threonine kinase that regulates many aspects of lipid and energy metabolism, although its specific role in controlling macrophage foam cell cholesterol homeostasis remains unclear. Methods: We sought to address this question by testing the effects of …
Authors
Fullerton MD; McGregor CP; LeBlond ND; Snider SA; Ford RJ; Austin RC; Steinberg GR; Kemp BE
Journal
Arteriosclerosis Thrombosis and Vascular Biology, Vol. 35, No. suppl_1,
Publisher
Wolters Kluwer
Publication Date
May 2015
DOI
10.1161/atvb.35.suppl_1.533
ISSN
1079-5642