Journal article
ACLY and CKD: A Mendelian Randomization Analysis
Abstract
Introduction: Adenosine triphosphate-citrate lyase (ACLY) inhibition is a therapeutic strategy under investigation for atherosclerotic cardiovascular disease, nonalcoholic steatohepatitis, and metabolic syndrome. Mouse models suggest that ACLY inhibition could reduce inflammation and kidney fibrosis. Genetic analysis of ACLY in chronic kidney disease (CKD) has not been performed.
Methods: We constructed a genetic instrument by selecting …
Authors
Mohammadi-Shemirani P; Chong M; Perrot N; Pigeyre M; Steinberg GR; Paré G; Krepinsky JC; Lanktree MB
Journal
Kidney International Reports, Vol. 7, No. 7, pp. 1673–1681
Publisher
Elsevier
Publication Date
July 2022
DOI
10.1016/j.ekir.2022.04.013
ISSN
2468-0249