Journal article
Ciliary Neurotrophic Factor Suppresses Hypothalamic AMP-Kinase Signaling in Leptin-Resistant Obese Mice
Abstract
We examined the actions of a second-generation ciliary neurotrophic factor analog (CNTF(Ax15)) on AMP-activated protein kinase (AMPK), a known regulator of food intake. Unlike leptin CNTF(Ax15) has been shown to reduce food intake in obese rodents and humans. Intraperitoneal injection of CNTF(Ax15) acutely (45 min) reduced hypothalamic AMPKalpha2 activity, AMPKalpha2Thr172 phosphorylation, and acetyl-coenzyme A carboxylase phosphorylation, …
Authors
Steinberg GR; Watt MJ; Fam BC; Proietto J; Andrikopoulos S; Allen AM; Febbraio MA; Kemp BE
Journal
Endocrinology, Vol. 147, No. 8, pp. 3906–3914
Publisher
The Endocrine Society
Publication Date
August 2006
DOI
10.1210/en.2005-1587
ISSN
0013-7227