Journal article
The Suppressor of Cytokine Signaling 3 Inhibits Leptin Activation of AMP-Kinase in Cultured Skeletal Muscle of Obese Humans
Abstract
CONTEXT: Leptin is thought to regulate whole-body adiposity and insulin sensitivity, at least in part, by stimulating fatty acid metabolism via activation of AMP-kinase (AMPK) in skeletal muscle. Human obesity is associated with leptin resistance, and recent studies have demonstrated that hypothalamic expression of the suppressors of cytokine signaling 3 (SOCS3) regulates leptin sensitivity in rodents.
OBJECTIVE: The objective of the study was …
Authors
Steinberg GR; McAinch AJ; Chen MB; O’Brien PE; Dixon JB; Cameron-Smith D; Kemp BE
Journal
The Journal of Clinical Endocrinology & Metabolism, Vol. 91, No. 9, pp. 3592–3597
Publisher
The Endocrine Society
Publication Date
September 1, 2006
DOI
10.1210/jc.2006-0638
ISSN
0021-972X
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
Adenylate KinaseAdultAminoimidazole CarboxamideEnzyme ActivationFemaleHumansHypoglycemic AgentsLeptinMaleMuscle Fibers, SkeletalMuscle, SkeletalObesityPalmitatesPhosphorylationRNA, MessengerReverse Transcriptase Polymerase Chain ReactionRibonucleotidesSignal TransductionSuppressor of Cytokine Signaling 3 ProteinSuppressor of Cytokine Signaling Proteins