Journal article
Impaired Activation of AMP-Kinase and Fatty Acid Oxidation by Globular Adiponectin in Cultured Human Skeletal Muscle of Obese Type 2 Diabetics
Abstract
Adiponectin is an adipocyte-derived hormone associated with antidiabetic actions. In rodent skeletal muscle, globular adiponectin (gAD) activates AMP-kinase (AMPK) and stimulates fatty acid oxidation effects mediated through the adiponectin receptors, AdipoR1 and AdipoR2. In the present study, we examined the mRNA expression of adiponectin receptors and the effects of gAD on AMPK activity and fatty acid oxidation in skeletal muscle myotubes …
Authors
Chen MB; McAinch AJ; Macaulay SL; Castelli LA; O’Brien PE; Dixon JB; Cameron-Smith D; Kemp BE; Steinberg GR
Journal
The Journal of Clinical Endocrinology & Metabolism, Vol. 90, No. 6, pp. 3665–3672
Publisher
The Endocrine Society
Publication Date
June 2005
DOI
10.1210/jc.2004-1980
ISSN
0021-972X