Journal article
Regulation of HSL serine phosphorylation in skeletal muscle and adipose tissue
Abstract
Hormone-sensitive lipase (HSL) is important for the degradation of triacylglycerol in adipose and muscle tissue, but the tissue-specific regulation of this enzyme is not fully understood. We investigated the effects of adrenergic stimulation and AMPK activation in vitro and in circumstances where AMPK activity and catecholamines are physiologically elevated in humans in vivo (during physical exercise) on HSL activity and phosphorylation at …
Authors
Watt MJ; Holmes AG; Pinnamaneni SK; Garnham AP; Steinberg GR; Kemp BE; Febbraio MA
Journal
AJP Endocrinology and Metabolism, Vol. 290, No. 3, pp. e500–e508
Publisher
American Physiological Society
Publication Date
March 2006
DOI
10.1152/ajpendo.00361.2005
ISSN
0193-1849
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
3T3-L1 CellsAMP-Activated Protein KinasesAdipose TissueAdrenergic AgonistsAdultAminoimidazole CarboxamideAnimalsBiopsy, Fine-NeedleEnzyme ActivatorsEpinephrineExerciseFemaleHumansMaleMiceMultienzyme ComplexesMuscle, SkeletalPhosphorylationProtein Serine-Threonine KinasesRibonucleotidesSerineSterol EsteraseTriglycerides