Journal article
Two isoprenylated flavonoids from Dorstenia psilurus activate AMPK, stimulate glucose uptake, inhibit glucose production and lower glycemia.
Abstract
Root extracts of a Cameroon medicinal plant, Dorstenia psilurus, were purified by screening for AMP-activated protein kinase (AMPK) activation in incubated mouse embryo fibroblasts (MEFs). Two isoprenylated flavones that activated AMPK were isolated. Compound 1 was identified as artelasticin by high-resolution electrospray ionization mass spectrometry and 2D-NMR while its structural isomer, compound 2, was isolated for the first time and …
Authors
Choumessi AT; Johanns M; Beaufay C; Herent M-F; Stroobant V; Vertommen D; Corbet C; Jacobs R; Herinckx G; Steinberg GR
Journal
Biochemical Journal, Vol. 476, No. 24, pp. 3687–3704
Publisher
Portland Press
Publication Date
December 19, 2019
DOI
10.1042/bcj20190326
ISSN
0264-6021