Journal article
Tumor necrosis factor α-induced skeletal muscle insulin resistance involves suppression of AMP-kinase signaling
Abstract
Elevated levels of tumor necrosis factor (TNFalpha) are implicated in the development of insulin resistance, but the mechanisms mediating these chronic effects are not completely understood. We demonstrate that TNFalpha signaling through TNF receptor (TNFR) 1 suppresses AMPK activity via transcriptional upregulation of protein phosphatase 2C (PP2C). This in turn reduces ACC phosphorylation, suppressing fatty-acid oxidation, increasing …
Authors
Steinberg GR; Michell BJ; van Denderen BJW; Watt MJ; Carey AL; Fam BC; Andrikopoulos S; Proietto J; Görgün CZ; Carling D
Journal
Cell Metabolism, Vol. 4, No. 6, pp. 465–474
Publisher
Elsevier
Publication Date
December 2006
DOI
10.1016/j.cmet.2006.11.005
ISSN
1550-4131