Journal article
AMPK regulation of fatty acid metabolism and mitochondrial biogenesis: Implications for obesity
Abstract
Skeletal muscle plays an important role in regulating whole-body energy expenditure given it is a major site for glucose and lipid oxidation. Obesity and type 2 diabetes are causally linked through their association with skeletal muscle insulin resistance, while conversely exercise is known to improve whole body glucose homeostasis simultaneously with muscle insulin sensitivity. Exercise activates skeletal muscle AMP-activated protein kinase …
Authors
O’Neill HM; Holloway GP; Steinberg GR
Journal
Molecular and Cellular Endocrinology, Vol. 366, No. 2, pp. 135–151
Publisher
Elsevier
Publication Date
2 2013
DOI
10.1016/j.mce.2012.06.019
ISSN
0303-7207