Journal article
Growth differentiation factor 15 (GDF15) predicts relapse free and overall survival in unresected locally advanced non-small cell lung cancer treated with chemoradiotherapy
Abstract
IntroductionGrowth differentiation factor 15 (GDF15) is a cytokine of the TGFβ family. Here, we analyzed GDF15 levels in patients with locally advanced non-small cell lung cancer (LA-NSCLC) who participated in OCOG-ALMERA (NCT02115464), a phase II randomized clinical trial, that investigated metformin in combination with standard of care concurrent chemoradiotherapy (cCRT). OCOG-ALMERA was not able to demonstrate benefit in the metformin arm. …
Authors
Di Pastena F; Pond G; Tsakiridis EE; Gouveia A; Ahmadi E; Biziotis O-D; Ali A; Swaminath A; Okawara G; Ellis PM
Journal
Radiation Oncology, Vol. 19, No. 1,
Publisher
Springer Nature
DOI
10.1186/s13014-024-02546-y
ISSN
1748-717X