New insights into activation and function of the AMPK Journal Articles

abstract

• The classical role of AMP-activated protein kinase (AMPK) is as a cellular energy sensor activated by falling energy status, signalled by increases in AMP to ATP and ADP to ATP ratios. Once activated, AMPK acts to restore energy homeostasis by promoting ATP-producing catabolic pathways while inhibiting energy-consuming processes. In this Review, we provide an update on this canonical (AMP/ADP-dependent) activation mechanism, but focus mainly on recently described non-canonical pathways, including those by which AMPK senses the availability of glucose, glycogen or fatty acids and by which it senses damage to lysosomes and nuclear DNA. We also discuss new findings on the regulation of carbohydrate and lipid metabolism, mitochondrial and lysosomal homeostasis, and DNA repair. Finally, we discuss the role of AMPK in cancer, obesity, diabetes, nonalcoholic steatohepatitis (NASH) and other disorders where therapeutic targeting may exert beneficial effects.

authors

• Steinberg, Gregory
• Hardie, D Grahame

status

• published 

publication date

• April 2023

has subject area

• 06 Biological Sciences (FoR)
• 11 Medical and Health Sciences (FoR)
• AMP-Activated Protein Kinases (MeSH)
• Adenosine Triphosphate (MeSH)
• Developmental Biology (Science Metrix)
• Energy Metabolism (MeSH)
• Glucose (MeSH)
• Lipid Metabolism (MeSH)

published in

• Nature Reviews Molecular Cell Biology  Journal

keywords

• AMP-Activated Protein Kinases
• Adenosine Triphosphate
• Energy Metabolism
• Glucose
• Lipid Metabolism

Digital Object Identifier (DOI)

• 10.1038/s41580-022-00547-x

PubMed ID

• 36316383

start page

• 255

end page

• 272

volume

• 24

issue

• 4