Journal article
Thienopyridone Drugs Are Selective Activators of AMP-Activated Protein Kinase β1-Containing Complexes
Abstract
The AMP-activated protein kinase (AMPK) is an alphabetagamma heterotrimer that plays a pivotal role in regulating cellular and whole-body metabolism. Activation of AMPK reverses many of the metabolic defects associated with obesity and type 2 diabetes, and therefore AMPK is considered a promising target for drugs to treat these diseases. Recently, the thienopyridone A769662 has been reported to directly activate AMPK by an unexpected mechanism. …
Authors
Scott JW; van Denderen BJW; Jorgensen SB; Honeyman JE; Steinberg GR; Oakhill JS; Iseli TJ; Koay A; Gooley PR; Stapleton D
Journal
Cell Chemical Biology, Vol. 15, No. 11, pp. 1220–1230
Publisher
Elsevier
Publication Date
November 2008
DOI
10.1016/j.chembiol.2008.10.005
ISSN
2451-9456