Journal article
Chronic modulation of AMP-Kinase, Akt and mTOR pathways by ionizing radiation in human lung cancer xenografts
Abstract
IntroductionEarlier, we showed that in cancer cells, AMP-activated kinase (AMPK) participates in a signal transduction pathway involving ATM-AMPK-p53/p21cip1 which is activated by ionizing radiation (IR) to mediate G2-M arrest and enhanced cytotoxicity. We also observed that AMPK modulates ATM expression and activity and the IR response of the Akt-mTOR pathway. Since the ATM, AMPK and Akt pathways are key targets of novel radio-sensitizing …
Authors
Storozhuk Y; Sanli T; Hopmans SN; Schultz C; Farrell T; Cutz J-C; Steinberg GR; Wright J; Singh G; Tsakiridis T
Journal
Radiation Oncology, Vol. 7, No. 1,
Publisher
Springer Nature
Publication Date
December 2012
DOI
10.1186/1748-717x-7-71
ISSN
1748-717X