Journal article
Maternal obesity alters fatty acid oxidation, AMPK activity, and associated DNA methylation in mesenchymal stem cells from human infants
Abstract
OBJECTIVE: Infants born to mothers with obesity have greater adiposity, ectopic fat storage, and are at increased risk for childhood obesity and metabolic disease compared with infants of normal weight mothers, though the cellular mechanisms mediating these effects are unclear.
METHODS: We tested the hypothesis that human, umbilical cord-derived mesenchymal stem cells (MSCs) from infants born to obese (Ob-MSC) versus normal weight (NW-MSC) …
Authors
Boyle KE; Patinkin ZW; Shapiro ALB; Bader C; Vanderlinden L; Kechris K; Janssen RC; Ford RJ; Smith BK; Steinberg GR
Journal
Molecular Metabolism, Vol. 6, No. 11, pp. 1503–1516
Publisher
Elsevier
Publication Date
11 2017
DOI
10.1016/j.molmet.2017.08.012
ISSN
2212-8778
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AMP-Activated Protein KinasesAcetyl-CoA CarboxylaseAdultCarnitine O-PalmitoyltransferaseDNA MethylationFatty AcidsFemaleHumansInfantInfant, NewbornLipid MetabolismMaleMembrane ProteinsMesenchymal Stem CellsMothersMuscle DevelopmentObesityOxidation-ReductionPediatric ObesityPregnancyPrenatal Exposure Delayed EffectsUmbilical CordYoung Adult