Metformin and salicylate synergistically activate liver AMPK, inhibit lipogenesis and improve insulin sensitivity Academic Article uri icon

  •  
  • Overview
  •  
  • Research
  •  
  • Identity
  •  
  • Additional Document Info
  •  
  • View All
  •  

abstract

  • Combining low, clinically relevant doses of metformin and salicylate synergistically activate AMPK, lower liver lipids and improve insulin sensitivity, and may be effective for treating non-alcoholic fatty liver disease and type II diabetes.

authors

  • Ford, Rebecca J
  • Fullerton, Morgan D
  • Pinkosky, Stephen L
  • Day, Emily A
  • Scott, John W
  • Oakhill, Jonathan S
  • Bujak, Adam L
  • Smith, Brennan K
  • Crane, Justin D
  • Blümer, Regje M
  • Marcinko, Katarina
  • Kemp, Bruce E
  • Gerstein, Hertzel Chaim
  • Steinberg, Gregory

publication date

  • May 15, 2015

has subject area