Journal article
AMP-activated protein kinase (AMPK) beyond metabolism
Abstract
AMP-activated protein kinase (AMPK), an established metabolic stress sensor, has gained popularity in cancer biology due to its ability to control cellular growth and mediate cell cycle checkpoints in cancer cells in response to low energy levels. AMPK is a key effector of the tumor suppressor liver kinase B 1 (LKB1) which inhibits the cellular growth mediator mammalian target of rapamycin (mTOR) and activates checkpoint mediators such as p53 …
Authors
Sanli T; Steinberg GR; Singh G; Tsakiridis T
Journal
Cancer Biology & Therapy, Vol. 15, No. 2, pp. 156–169
Publisher
Taylor & Francis
Publication Date
2 2014
DOI
10.4161/cbt.26726
ISSN
1538-4047