Restoration of hepatic TDAG51 expression improves insulin signaling and reduces weight gain in mouse models of non‐alcoholic fatty liver disease

The absence of T‐cell death‐associated gene 51 (TDAG51) in mice results in late‐onset insulin resistance (IR), obesity and hepatic steatosis. In support of these findings, mice fed a high fat diet, which leads to IR and obesity, as well as the leptin‐deficient mouse model, a well‐established genetic model of type 2 diabetes and obesity, show significantly diminished hepatic TDAG51 protein levels. Here we report that hepatic TDAG51 protein …