Skeletal Muscle‐Specific Deletion of AMPKβ1β2 Modulates Age‐Induced Neuromuscular Junction Remodeling in Fast Glycolytic Muscles

The neuromuscular junction (NMJ) is the electrochemical signaling apparatus between an ⍺‐motoneuron and the skeletal muscle fibers that it innervates. AMP‐activated protein kinase (AMPK) regulates neuromuscular phenotype. However, the precise role of this kinase at the NMJ has yet to be elucidated. The purpose of the current study was to examine the role of skeletal muscle AMPK on NMJ biology across the lifespan. We utilized 3‐ and 12‐month‐old …