DNA Damage Concept

subject area of

• A Novel Aspect of Tumorigenesis—BMI1 Functions in Regulating DNA Damage Response  Academic Article
• A Novel Non-canonical Forkhead-associated (FHA) Domain-binding Interface Mediates the Interaction between Rad53 and Dbf4 Proteins*  Academic Article
• A Role of p73 in Mitotic Exit  Academic Article
• A Two-Species Biomarker Model for the Assessment of Sediment Toxicity in the Marine and Estuarine Environment Using the Comet Assay  Academic Article
• A combination of MSH2 DNA mismatch repair deficiency and expression of the SV40 large T antigen results in cisplatin resistance of mouse embryonic fibroblasts  Academic Article
• A multiplexable assay for screening antibiotic lethality against drug-tolerant bacteria  Academic Article
• A novel form of ataxia oculomotor apraxia characterized by oxidative stress and apoptosis resistance  Academic Article
• A preliminary analysis of the DNA and diet of the extinct Beothuk: A systematic approach to ancient human DNA  Academic Article
• A unifying mechanism in neurodegeneration  Academic Article
• AMP-activated protein kinase (AMPK) beyond metabolism  Academic Article
• APE2 Zf-GRF facilitates 3′-5′ resection of DNA damage following oxidative stress  Academic Article
• ATM and ATR Signaling Regulate the Recruitment of Human Telomerase to Telomeres  Academic Article
• Abrogation of G2 checkpoint specifically sensitize p53 defective cells to cancer chemotherapeutic agents.  Academic Article
• Accelerated decline in lung function in cigarette smokers is associated with TP53/MDM2 polymorphisms  Academic Article
• Actions of radiation on living cells in the “post-bystander” era  Academic Article
• Adaptation in bacterial CRISPR-Cas immunity can be driven by defective phages  Academic Article
• Adaptive response in frogs chronically exposed to low doses of ionizing radiation in the environment  Academic Article
• Aging, oxidative responses, and proliferative capacity in cultured mouse aortic smooth muscle cells  Academic Article
• Air pollution induces heritable DNA mutations  Academic Article
• Analysis of DNA repair in XP–HeLa hybrids; lack of correlation between excision repair of u.v. damage and adenovirus reactivation in an XP(D)-like cell line  Academic Article
• Assessment of DNA Oxidation and Antioxidant Activity in Hypertensive Patients with Chronic Kidney Disease  Academic Article
• BMI1 attenuates etoposide-induced G2/M checkpoints via reducing ATM activation  Academic Article
• BRD4 prevents the accumulation of R-loops and protects against transcription–replication collision events and DNA damage  Academic Article
• Benign tumors from the human nervous system express high levels of survivin and are resistant to spontaneous and radiation-induced apoptosis  Academic Article
• Biphasic recruitment of TRF2 to DNA damage sites promotes non-sister chromatid homologous recombination repair  Academic Article
• Blockage of melatonin receptors impairs p53-mediated prevention of DNA damage accumulation  Academic Article
• Both ERK1 and ERK2 kinases promote G2/M arrest in etoposide-treated MCF7 cells by facilitating ATM activation  Academic Article
• Bystander Effects in Repair-Deficient Cell Lines  Academic Article
• Calculation of radiation-induced DNA damage from photons and tritium beta-particles  Academic Article
• Calculation of radiation-induced DNA damage from photons and tritium beta-particles  Academic Article
• Camptothecin-resistant mutants of Chinese hamster ovary cells containing a resistant form of topoisomerase I.  Academic Article
• Cdk-dependent phosphorylation regulates TRF1 recruitment to PML bodies and promotes C-circle production in ALT cells  Academic Article
• Cells differentiating into neuroectoderm undergo apoptosis in the absence of functional retinoblastoma family proteins.  Academic Article
• Cellular responses in rainbow trout (Oncorhynchus mykiss) reared in tritiated water and/or fed organically bound tritium  Academic Article
• Changing paradigms in radiobiology  Academic Article
• Che-1 Promotes Tumor Cell Survival by Sustaining Mutant p53 Transcription and Inhibiting DNA Damage Response Activation  Academic Article
• Che-1 modulates the decision between cell cycle arrest and apoptosis by its binding to p53  Academic Article
• Chromosomal damage induced by human adenovirus type 12 requires expression of the E1B 55-kilodalton viral protein.  Academic Article
• Cockayne syndrome group B protein regulates DNA double‐strand break repair and checkpoint activation  Academic Article
• Comment on "Whole-Genome Shotgun Sequencing of Mitochondria from Ancient Hair Shafts"  Academic Article
• Compromised genomic integrity impedes muscle growth after Atrx inactivation  Academic Article
• Contributions of DNA Damage to Alzheimer’s Disease  Academic Article
• Correlated responses for DNA damage, phagocytosis activity and lysosomal function revealed in a comparison between field and laboratory studies: Fathead minnow exposed to tritium  Academic Article
• Cross-resistance to photofrin-mediated photodynamic therapy and UV light and recovery from photodynamic therapy damage in Rif-8A mouse fibrosarcoma cells measured using viral capacity  Academic Article
• Crystallization of the DdrB–DNA complex fromDeinococcus radiodurans  Academic Article
• Cytogenetic dose–response and adaptive response in cells of ungulate species exposed to ionizing radiation  Academic Article
• DNA Damage Repair in Huntington’s Disease and Other Neurodegenerative Diseases  Academic Article
• DNA Damage and Biological Expression of Adenovirus: A Comparison of Liquid versus Frozen Conditions of Exposure to γ Rays  Academic Article
• DNA Damage-Dependent Acetylation of p73 Dictates the Selective Activation of Apoptotic Target Genes  Academic Article
• DNA Lesions That Signal the Induction of Radioresistance and DNA Repair in Yeast  Academic Article
• DNA Repair Signaling of Huntingtin: The Next Link Between Late-Onset Neurodegenerative Disease and Oxidative DNA Damage  Academic Article
• DNA damage in bipolar disorder  Academic Article
• DNA damage in rats after treatment with methylphenidate  Academic Article
• Deciphering and simulating models of radiation genotoxicity with CRISPR/Cas9 systems  Academic Article
• Defective repair of UV-damaged DNA in human tumor and SV40-transformed human cells but not in adenovirus-transformed human cells  Academic Article
• Deficient base excision repair of oxidative DNA damage induced by methylene blue plus visible light in xeroderma pigmentosum group C fibroblasts  Academic Article
• Degradation of nuclear matrix and DNA cleavage in apoptotic thymocytes.  Academic Article
• Delayed cell death and bystander effects in the progeny of Chinook Salmon Embryo cells exposed to radiation and a range of aquatic pollutants  Academic Article
• Delayed expression of lethal mutations and genomic instability in the progeny of human epithelial cells that survived in a bystander-killing environment  Academic Article
• Depletion of poly(ADP-ribose) polymerase-1 reduces host cell reactivation of a UV-damaged adenovirus-encoded reporter gene in human dermal fibroblasts  Academic Article
• Differential contribution of XPC, RAD23A, RAD23B and CENTRIN 2 to the UV-response in human cells  Academic Article
• Differential effects of hypoxia and acidosis on p53 expression, repair of UVC-damaged DNA and viability after UVC in normal and tumor-derived human cells  Academic Article
• Direct and delayed X-ray-induced DNA damage in male mouse germ cells  Academic Article
• ERK Activation Mediates Cell Cycle Arrest and Apoptosis after DNA Damage Independently of p53  Academic Article
• ERK activity facilitates activation of the S-phase DNA damage checkpoint by modulating ATR function  Academic Article
• ERK kinases modulate the activation of PI3 kinase related kinases (PIKKs) in DNA damage response.  Academic Article
• ERK1 and ERK2 kinases activate hydroxyurea-induced S-phase checkpoint in MCF7 cells by mediating ATR activation  Academic Article
• Early host cell reactivation of an oxidatively damaged adenovirus-encoded reporter gene requires the Cockayne syndrome proteins CSA and CSB  Academic Article
• Effects of mood stabilizers on DNA damage in an animal model of mania.  Academic Article
• Efficient UV repair requires disengagement of the CSB winged helix domain from the CSB ATPase domain  Academic Article
• Elevated DNA damage in a mouse model of oxidative stress: impacts of ionizing radiation and a protective dietary supplement  Academic Article
• Elevated G2 chromosomal radiosensitivity in Irish breast cancer patients: a comparison with other studies  Academic Article
• Endonuclease III and endonuclease IV protect Escherichia coli from the lethal and mutagenic effects of near-UV irradiation  Academic Article
• Enhanced expression from the human cytomegalovirus immediate-early promoter in a non-replicating adenovirus encoded reporter gene following cellular exposure to chemical DNA damaging agents  Academic Article
• Enhanced host cell reactivation of a UV-damaged reporter gene in pre-UV-treated cells is delayed in Cockayne syndrome cells  Academic Article
• Enhancing chemotherapy response through augmented synthetic lethality by co-targeting nucleotide excision repair and cell-cycle checkpoints  Academic Article
• Evidence for lack of mitochondrial DNA repair followingcis-dichlorodiammineplatinum treatment  Academic Article
• Exercise-induced protection of bone marrow cells following exposure to radiation  Academic Article
• Expression of an adenovirus encoded reporter gene and its reactivation following UVC and oxidative damage in cultured fish cells  Academic Article
• Expression of delayed toxicity and lethal mutations in the progeny of human cells surviving exposure to radiation and other environmental mutagens  Conference Paper
• Extracellular Signal-Regulated Kinases Modulate DNA Damage Response - A Contributing Factor to Using MEK Inhibitors in Cancer Therapy  Academic Article
• Fanconi’s Anemia Effect or Sickle Cell Anemia Effect: That is the Question  Academic Article
• From p63 to p53 across p73  Academic Article
• Gain of function mutant p53 proteins cooperate with E2F4 to transcriptionally downregulate RAD17 and BRCA1 gene expression  Academic Article
• Gain of function of mutant p53: The mutant p53/NF-Y protein complex reveals an aberrant transcriptional mechanism of cell cycle regulation  Academic Article
• Generation of a new adenovirus type 12-inducible fragile site by insertion of an artificial U2 locus in the human genome.  Academic Article
• Genetic Analyses from Ancient DNA  Academic Article
• Genomic instability, bystander effects and radiation risks: implications for development of protection strategies for man and the environment.  Academic Article
• Genotoxicity of field-collected inter-tidal sediments from Cork Harbor, Ireland, to juvenile turbot (Scophthalmus maximus L.) as measured by the Comet assay  Academic Article
• HIPK2 neutralizes MDM2 inhibition rescuing p53 transcriptional activity and apoptotic function  Academic Article
• Heat-induced thermal tolerance and radiation resistance to apoptosis in human lymphocytes  Academic Article
• Hepatic biomarkers of sediment-associated pollution in juvenile turbot, Scophthalmus maximus L.  Academic Article
• Host cell reactivation of gene expression for an adenovirus-encoded reporter gene reflects the repair of UVC-induced cyclobutane pyrimidine dimers and methylene blue plus visible light-induced 8-oxoguanine  Academic Article
• Host cell reactivation of irradiated adenovirus in UV-sensitive Chinese hamster ovary cell mutants  Academic Article
• Huntingtin is a scaffolding protein in the ATM oxidative DNA damage response complex  Academic Article
• Id2gene is a transcriptional target of the protein complex mutant p53/E2F1  Academic Article
• Implications of seasonal priming and reproductive activity on the interpretation of Comet assay data derived from the clam, Tapes semidecussatus Reeves 1864, exposed to contaminated sediments  Academic Article
• Increased expression of p53 enhances transcription-coupled repair and global genomic repair of a UVC-damaged reporter gene in human cells  Academic Article
• Increased oxidative stress and DNA damage in bipolar disorder: A twin-case report  Academic Article
• Indirect stimulation of recombination in Escherichia coli K-12: dependence on recJ, uvrA, and uvrD.  Academic Article
• Induction of Mdm2 and enhancement of cell survival by bFGF  Academic Article
• Inhibition of RNA polymerase II as a trigger for the p53 response  Academic Article
• Inhibition of p53 Transcriptional Activity by Bcl-2 Requires Its Membrane-anchoring Domain  Academic Article
• Initiation of Apoptosis in Cells Exposed to Medium from the Progeny of Irradiated Cells: A Possible Mechanism for Bystander-Induced Genomic Instability?  Academic Article
• Low-dose metronomic delivery of cyclophosphamide is less detrimental to granulosa cell viability, ovarian function, and fertility than maximum tolerated dose delivery in the mouse†  Academic Article
• Lower oxidative DNA damage despite greater ROS production in muscles from rats selectively bred for high running capacity  Academic Article
• Mathematical model for the cancer stem cell hypothesis  Academic Article
• Mechanisms and implications of genomic instability and other delayed effects of ionizing radiation exposure  Academic Article
• Melatonin triggers p53Ser phosphorylation and prevents DNA damage accumulation  Academic Article
• Menin Is a Regulator of the Stress Response in Drosophila melanogaster  Academic Article
• Metabolomic analysis of exercise effects in the POLG mitochondrial DNA mutator mouse brain  Academic Article
• Microvesicles Contribute to the Bystander Effect of DNA Damage  Academic Article
• Mitochondrial DNA damage by anticancer agents  Academic Article
• Mitochondrial DNA point mutations and a novel deletion induced by direct low-LET radiation and by medium from irradiated cells  Academic Article
• Mitochondrio‐nuclear translocation of AIF in apoptosis and necrosis  Academic Article
• Modelling DNA damage induced by different energy photons and tritium beta-particles  Academic Article
• Modulation of Radiation Responses by Pre-exposure to Irradiated Cell Conditioned Medium  Academic Article
• Modulation of radiation-induced strand break repair by cisplatin in mammalian cells  Academic Article
• Mutant p53 oncogenic functions are sustained by Plk2 kinase through an autoregulatory feedback loop  Academic Article
• N6-Furfuryladenine is protective in Huntington’s disease models by signaling huntingtin phosphorylation  Academic Article
• Neutron and Cobalt-60 γ Irradiation Produce Similar Changes in DNA Supercoiling  Academic Article
• New insights from old bones: DNA preservation and degradation in permafrost preserved mammoth remains  Academic Article
• Nitrogen mustard drug resistant B-cell chronic lymphocytic leukemia as an in vivo model for crosslinking agent resistance  Academic Article
• Non-cancer health effects of pesticides: systematic review and implications for family doctors.  Academic Article
• Noninvasive Markers of Oxidative DNA Stress, RNA Degradation and Protein Degradation Are Differentially Correlated With Resting Metabolic Rate and Energy Intake in Children and Adolescents  Academic Article
• Nucleotide excision repair in the human ovarian carcinoma cell line (2008) and its cisplatin-resistant variant (C13*)  Academic Article
• On the Road to Bacterial Cell Death  Academic Article
• Open-Source High-Throughput Phenomics of Bacterial Promoter-Reporter Strains  Academic Article
• Oxidative ecology of paternal care in wild smallmouth bass,Micropterus dolomieu  Academic Article
• Oxidative stress and the mitochondrial theory of aging in human skeletal muscle  Academic Article
• PHOTOCHEMISTRY, PHOTOPHYSICS, AND MECHANISM OF PYRIMIDINE DIMER REPAIR BY DNA PHOTOLYASE  Academic Article
• Pancratistatin Selectively Targets Cancer Cell Mitochondria and Reduces Growth of Human Colon Tumor Xenografts  Academic Article
• Pancratistatin causes early activation of caspase-3 and the flipping of phosphatidyl serine followed by rapid apoptosis specifically in human lymphoma cells  Academic Article
• Persistent DNA damage induced by ultraviolet light inhibits p21waf1 and bax expression: implications for DNA repair, UV sensitivity and the induction of apoptosis  Academic Article
• Pin1 Links the Activities of c-Abl and p300 in Regulating p73 Function  Academic Article
• Placental Transforming Growth Factor-β Is a Downstream Mediator of the Growth Arrest and Apoptotic Response of Tumor Cells to DNA Damage and p53 Overexpression  Academic Article
• Poly(ADP-ribose) polymerase can bind melphalan damaged DNA.  Academic Article
• Poly(ADP-ribose) polymerase-1, DNA repair and mammalian longevity  Academic Article
• Promyelocytic Leukemia Protein is Required for Gain of Function by Mutant p53  Academic Article
• Prostate cancer stem-like cells proliferate slowly and resist etoposide-induced cytotoxicity via enhancing DNA damage response  Academic Article
• Quantifying murine bone marrow and blood radiation dose response following 18F-FDG PET with DNA damage biomarkers  Academic Article
• RELATIVE REPAIR OF ADENOVIRUS DAMAGED BY SUNLAMP, UV AND γ-IRRADIATION IN COCKAYNE SYNDROME FIBROBLASTS IS DIFFERENT FROM THAT IN XERODERMA PIGMENTOSUM FIBROBLASTS  Academic Article
• Radiation-induced DNA damage and the relative biological effectiveness of 18F-FDG in wild-type mice  Academic Article
• Radiation-induced bystander effects and the DNA paradigm: An “out of field” perspective  Academic Article
• Radiation-induced non-targeted effects: some open questions  Academic Article
• Radiosensitization of glioma cells by modulation of Met signalling with the hepatocyte growth factor neutralizing antibody, AMG102  Academic Article
• Recharacterization of ancient DNA miscoding lesions: insights in the era of sequencing-by-synthesis  Academic Article
• Recognition and repair of chemically heterogeneous structures at DNA ends  Academic Article
• Reduced host cell reactivation of oxidative DNA damage in human cells deficient in the mismatch repair gene hMSH2  Academic Article
• Reduced host cell reactivation of oxidatively damaged DNA in ageing human fibroblasts  Academic Article
• Relationship between clonogenic radiosensitivity, radiation-induced apoptosis and DNA damage/repair in human colon cancer cells  Academic Article
• Renal excretion of 8-oxo-7,8-dihydro-2′-deoxyguanosine: degradation rates of RNA and metabolic rate in humans  Academic Article
• Repair of Radiation-Induced DNA Breaks in Human Adenovirus  Academic Article
• Rescue of Hippo coactivator YAP1 triggers DNA damage–induced apoptosis in hematological cancers  Academic Article
• Research strategies for the prevention of early events in human radiation carcinogenesis Report on the 7th LH Gray Workshop held in the Radiation Science Centre, Dublin from 5th-8th December 1996  Academic Article
• Resistance exercise training decreases oxidative damage to DNA and increases cytochrome oxidase activity in older adults  Academic Article
• Resveratrol, a natural aryl hydrocarbon receptor antagonist, protects lung from DNA damage and apoptosis caused by benzo[a]pyrene  Academic Article
• Resveratrol, a natural aryl hydrocarbon receptor antagonist, protects sperm from DNA damage and apoptosis caused by benzo(a)pyrene  Academic Article
• Role of Fapy Glycosylase and UvrABC Excinuclease in the Repair of UVA (320-400 nm)-mediated DNA Damage in Escherichia coli  Academic Article
• Role of RAD9-dependent cell-cycle checkpoints in the adaptive response to ionizing radiation in yeast, Saccharomyces cerevisiae  Academic Article
• Role of proteolysis in apoptosis: involvement of serine proteases in internucleosomal DNA fragmentation in immature thymocytes  Academic Article
• S100A2 gene is a direct transcriptional target of p53 homologues during keratinocyte differentiation  Academic Article
• Skeletal Muscle Aging in F344BN F1-Hybrid Rats: I. Mitochondrial Dysfunction Contributes to the Age-Associated Reduction in VO2max  Academic Article
• Structurally simplified biphenyl combretastatin A4 derivatives retain in vitro anti-cancer activity dependent on mitotic arrest  Academic Article
• Structure-specific endonuclease activity of SNM1A enables processing of a DNA interstrand crosslink  Academic Article
• Surveying the repair of ancient DNA from bones via high-throughput sequencing  Academic Article
• Synergism between aphidicolin and adenoviruses in the induction of breaks at fragile sites on human chromosomes  Academic Article
• Targets, pools, shoulders, and communication – a reflection on the evolution of low-dose radiobiology  Academic Article
• Telomere crisis in kidney epithelial cells promotes the acquisition of a microRNA signature retrieved in aggressive renal cell carcinomas  Academic Article
• The E3 ubiquitin ligase Mule acts through the ATM–p53 axis to maintain B lymphocyte homeostasis  Academic Article
• The Effects of Low-Level Laser Light Exposure on Sperm Motion Characteristics and DNA Damage  Academic Article
• The Genetic Secrets Some Fossils Hold  Academic Article
• The Influence of Track Structure on the Understanding of Relative Biological Effectiveness for Induction of Chromosomal Exchanges in Human Lymphocytes  Academic Article
• The Transcriptional Coactivator Yes-Associated Protein Drives p73 Gene-Target Specificity in Response to DNA Damage  Academic Article
• The association between glutathione S-transferase M1 genotype and polycyclic aromatic hydrocarbon-DNA adducts in breast tissue.  Academic Article
• The bromodomain protein Brd4 insulates chromatin from DNA damage signalling  Academic Article
• The cellular environment in computer simulations of radiation-induced damage to DNA  Academic Article
• The methylenetetrahydrofolate reductase C677T mutation induces cell-specific changes in genomic DNA methylation and uracil misincorporation: A possible molecular basis for the site-specific cancer risk modification  Academic Article
• The p53/p21 DNA damage-signaling pathway is defective in most meningioma cells  Academic Article
• The prolyl isomerase Pin1 reveals a mechanism to control p53 functions after genotoxic insults  Academic Article
• The relationship between genetic damage from polycyclic aromatic hydrocarbons in breast tissue and breast cancer  Academic Article
• The role of O6-alkylguanine-DNA alkyltransferase in protecting Rat4 cells against the mutagenic effects of O6-substituted guanine residues incorporated in codon 12 of the H-ras gene  Academic Article
• The structure of DdrB from Deinococcus: a new fold for single-stranded DNA binding proteins  Academic Article
• The transcriptionally competent U2 gene is necessary and sufficient for adenovirus type 12 induction of the fragile site at 17q21-22.  Academic Article
• UV-inducible base excision repair of oxidative damaged DNA in human cells  Academic Article
• Ultrasound Imaging of Apoptosis: Spectroscopic Detection of DNA-Damage Effects In Vivo  Academic Article
• Ultrasound Imaging of Apoptosis: Spectroscopic Detection of DNA-Damage Effects at High and Low Frequencies  Academic Article
• Ultrasound Imaging of DNA-Damage Effects in Live Cultured Cells and in Brain Tissue  Academic Article
• Unraveling the Complexities of DNA-Dependent Protein Kinase Autophosphorylation  Academic Article
• Use of the Dual Potential to Rationalize the Occurrence of Some DNA Lesions (Pyrimidic Dimers)  Academic Article
• Validated or Not Validated? That Is the Question  Academic Article
• Variation in the expression of p53, c-myc, and bcl-2 oncoproteins in individual patient cultures of normal urothelium exposed to cobalt 60 gamma-rays and N-nitrosodiethanolamine.  Academic Article
• Wild-type p53 modulates apoptosis of normal, IL-3 deprived, hematopoietic cells.  Academic Article
• XRCC4's interaction with XLF is required for coding (but not signal) end joining  Academic Article
• p73-Mediated Chemosensitivity: A Preferential Target of Oncogenic Mutant p53  Academic Article
• γ-H2AX as a Marker for Dose Deposition in the Brain of Wistar Rats after Synchrotron Microbeam Radiation  Academic Article