Journal article
Contributions of DNA Damage to Alzheimer’s Disease
Abstract
Alzheimer's disease (AD) is the most common type of neurodegenerative disease. Its typical pathology consists of extracellular amyloid-β (Aβ) plaques and intracellular tau neurofibrillary tangles. Mutations in the APP, PSEN1, and PSEN2 genes increase Aβ production and aggregation, and thus cause early onset or familial AD. Even with this strong genetic evidence, recent studies support AD to result from complex etiological alterations. Among …
Authors
Lin X; Kapoor A; Gu Y; Chow MJ; Peng J; Zhao K; Tang D
Journal
International Journal of Molecular Sciences, Vol. 21, No. 5,
Publisher
MDPI
DOI
10.3390/ijms21051666
ISSN
1661-6596