Che-1 Promotes Tumor Cell Survival by Sustaining Mutant p53 Transcription and Inhibiting DNA Damage Response Activation Journal Articles uri icon

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  • Che-1 is a RNA polymerase II binding protein involved in the regulation of gene transcription and, in response to DNA damage, promotes p53 transcription. In this study, we investigated whether Che-1 regulates mutant p53 expression. We found that Che-1 is required for sustaining mutant p53 expression in several cancer cell lines, and that Che-1 depletion by siRNA induces apoptosis both in vitro and in vivo. Notably, loss of Che-1 activates DNA damage checkpoint response and induces transactivation of p73. Therefore, these findings underline the important role that Che-1 has in survival of cells expressing mutant p53.


  • Bruno, Tiziana
  • Desantis, Agata
  • Bossi, Gianluca
  • Di Agostino, Silvia
  • Sorino, Cristina
  • De Nicola, Francesca
  • Iezzi, Simona
  • Franchitto, Annapaola
  • Benassi, Barbara
  • Galanti, Sergio
  • La Rosa, Francesca
  • Floridi, Aristide
  • Bellacosa, Alfonso
  • Passananti, Claudio
  • Blandino, Giovanni
  • Fanciulli, Maurizio

publication date

  • August 2010

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