Journal article
Both ERK1 and ERK2 kinases promote G2/M arrest in etoposide-treated MCF7 cells by facilitating ATM activation
Abstract
The MEK-ERK pathway plays a role in DNA damage response (DDR). This has been thoroughly studied by modulating MEK activation. However, much less has been done to directly examine the contributions of ERK1 and ERK2 kinases to DDR. Etoposide induces G2/M arrest in a variety of cell lines, including MCF7 cells. DNA damage-induced G2/M arrest depends on the activation of the protein kinase ataxia-telangiectasia mutated (ATM). ATM subsequently …
Authors
Wei F; Xie Y; Tao L; Tang D
Journal
Cellular Signalling, Vol. 22, No. 11, pp. 1783–1789
Publisher
Elsevier
Publication Date
11 2010
DOI
10.1016/j.cellsig.2010.07.007
ISSN
0898-6568
Fields of Research (FoR)
Medical Subject Headings (MeSH)
Ataxia Telangiectasia Mutated ProteinsCell Cycle ProteinsCell DivisionCell Line, TumorCheckpoint Kinase 2DNA DamageDNA-Binding ProteinsEtoposideG2 PhaseHistonesHumansMitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3PhosphorylationProtein Serine-Threonine KinasesRNA InterferenceRNA, Small InterferingTumor Suppressor Proteinscdc25 Phosphatases