Rescue of Hippo coactivator YAP1 triggers DNA damage–induced apoptosis in hematological cancers

Tumor cells of epithelial origin present rampant DNA damage but do not undergo apoptosis due to inactivation of TP53. Understanding the mechanisms by which tumor cells are protected from cell death is crucial for identifying new therapeutic targets. Cottini et al. report that hematological malignancies also present DNA damage and a distinct, TP53-independent mechanism for evading cell death: low levels of the Hippo pathway coactivator YAP1 …