Journal article
Camptothecin-resistant mutants of Chinese hamster ovary cells containing a resistant form of topoisomerase I.
Abstract
In Chinese hamster ovary cells, stable mutants that exhibit 250- to 350-fold resistance to camptothecin (CptR mutants) have been isolated from mutagen-treated cultures. The CptR mutants exhibited no cross-resistance towards drugs such as colchicine, vinblastine, taxol, or puromycin but showed slightly (2- to 3-fold) enhanced sensitivity towards various drugs that inhibit DNA topoisomerase II (namely teniposide, etoposide, doxorubicin, …
Authors
Gupta RS; Gupta R; Eng B; Lock RB; Ross WE; Hertzberg RP; Caranfa MJ; Johnson RK
Journal
Cancer Research, Vol. 48, No. 22, pp. 6404–6410
Publication Date
November 15, 1988
ISSN
0008-5472