Journal article
Placental Transforming Growth Factor-β Is a Downstream Mediator of the Growth Arrest and Apoptotic Response of Tumor Cells to DNA Damage and p53 Overexpression*
Abstract
The p53 tumor suppressor gene and members of the transforming growth factor-beta (TGF-beta) superfamily play central roles in signaling cell cycle arrest and apoptosis (programmed cell death) in normal development and differentiation, as well as in carcinogenesis. Here we describe a distantly related member of the TGF-beta superfamily, designated placental TGF-beta (PTGF-beta), that is up-regulated in response to both p53-dependent and …
Authors
Li P-X; Wong J; Ayed A; Ngo D; Brade AM; Arrowsmith C; Austin RC; Klamut HJ
Journal
Journal of Biological Chemistry, Vol. 275, No. 26, pp. 20127–20135
Publisher
Elsevier
Publication Date
June 2000
DOI
10.1074/jbc.m909580199
ISSN
0021-9258
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AdenoviridaeApoptosisBlotting, NorthernBreast NeoplasmsCell CycleCell DivisionCell SurvivalDNA DamageDNA, ComplementaryGenes, p53Genetic VectorsGrowth SubstancesHumansPregnancy ProteinsRNA, MessengerSequence Analysis, DNATime FactorsTissue DistributionTranscriptional ActivationTumor Cells, CulturedTumor Suppressor Protein p53Up-Regulation