Journal article
Metabolomic analysis of exercise effects in the POLG mitochondrial DNA mutator mouse brain
Abstract
Mitochondrial DNA (mtDNA) mutator mice express a mutated form of mtDNA polymerase gamma that results an accelerated accumulation of somatic mtDNA mutations in association with a premature aging phenotype. An exploratory metabolomic analysis of cortical metabolites in sedentary and exercised mtDNA mutator mice and wild-type littermate controls at 9-10 months of age was performed. Pathway analysis revealed deficits in the neurotransmitters …
Authors
Clark-Matott J; Saleem A; Dai Y; Shurubor Y; Ma X; Safdar A; Beal MF; Tarnopolsky M; Simon DK
Journal
Neurobiology of Aging, Vol. 36, No. 11, pp. 2972–2983
Publisher
Elsevier
Publication Date
November 2015
DOI
10.1016/j.neurobiolaging.2015.07.020
ISSN
0197-4580