Journal article
BMI1 attenuates etoposide-induced G2/M checkpoints via reducing ATM activation
Abstract
The BMI1 protein contributes to stem cell pluripotency and oncogenesis via multiple functions, including its newly identified role in DNA damage response (DDR). Although evidence clearly demonstrates that BMI1 facilitates the repair of double-stranded breaks via homologous recombination (HR), it remains unclear how BMI1 regulates checkpoint activation during DDR. We report here that BMI1 has a role in G2/M checkpoint activation in response to …
Authors
Wei F; Ojo D; Lin X; Wong N; He L; Yan J; Xu S; Major P; Tang D
Journal
Oncogene, Vol. 34, No. 23, pp. 3063–3075
Publisher
Springer Nature
Publication Date
June 4, 2015
DOI
10.1038/onc.2014.235
ISSN
0950-9232