Journal article
The Transcriptional Coactivator Yes-Associated Protein Drives p73 Gene-Target Specificity in Response to DNA Damage
Abstract
The transcriptional coactivator Yes-associated protein (YAP) has been shown to interact with and to enhance p73-dependent apoptosis in response to DNA damage. Here, we show that YAP requires the promyelocytic leukemia gene (PML) and nuclear body localization to coactivate p73. YAP imparts selectivity to p73 by promoting the activation of a subset of p53 and/or p73 target promoters. Endogenous p73, YAP, and p300 proteins are concomitantly …
Authors
Strano S; Monti O; Pediconi N; Baccarini A; Fontemaggi G; Lapi E; Mantovani F; Damalas A; Citro G; Sacchi A
Journal
Molecular Cell, Vol. 18, No. 4, pp. 447–459
Publisher
Elsevier
Publication Date
May 2005
DOI
10.1016/j.molcel.2005.04.008
ISSN
1097-2765
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AcetylationAntibiotics, AntineoplasticApoptosis Regulatory ProteinsCell Cycle ProteinsCisplatinDNA DamageDNA-Binding ProteinsDoxorubicinGenes, ReporterGenes, Tumor SuppressorHumansNeoplasm ProteinsNuclear ProteinsPromyelocytic Leukemia ProteinProteinsTrans-ActivatorsTranscription FactorsTranscription, GeneticTumor Protein p73Tumor Suppressor Proteins